Magnitude and time course of arterial vascular adaptations to inactivity in humans

We demonstrate that extensive arterial vascular adaptations occur within 3-8 wk of inactivity in humans. We put forth the hypothesis that the diameter decrease represents an adaptation to a lack of variation in peak shear stress. Furthermore, an enhanced flow-mediated dilation in deconditioned arter...

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Bibliographic Details
Published in:Exercise and sport sciences reviews 2006-04, Vol.34 (2), p.65-71
Main Authors: de Groot, Patricia C E, Bleeker, Michiel W P, Hopman, Maria T E
Format: Article
Language:English
Subjects:
Adaptation, Physiological - physiology
Arteries - physiology
Bed Rest
Blood Circulation - physiology
Blood Flow Velocity - physiology
Endothelium, Vascular - physiology
Endothelium, Vascular - physiopathology
Exercise - physiology
Humans
Motor Activity - physiology
Netherlands
Restraint, Physical - physiology
Vasodilation - physiology
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Summary:We demonstrate that extensive arterial vascular adaptations occur within 3-8 wk of inactivity in humans. We put forth the hypothesis that the diameter decrease represents an adaptation to a lack of variation in peak shear stress. Furthermore, an enhanced flow-mediated dilation in deconditioned arteries implies that functional vascular adaptations to inactivity are not simply the inverse of adaptations to exercise.
ISSN:0091-6331
DOI:10.1249/00003677-200604000-00005