Effects of Relaxin in a Model of Rat Adjuvant-Induced Arthritis

: A reduction in the incidence and severity of rheumatoid arthritis is seen in pregnant women. Relaxin, a hormone of pregnancy, has been implicated in decreased immune responsiveness. Consequently, the effects of relaxin and estradiol valerate, alone or in combination, were assessed in the developme...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2005-05, Vol.1041 (1), p.481-485
Main Authors: SANTORA, KAREN, RASA, CORDELIA, VISCO, DENISE, STEINETZ, BERNARD, BAGNELL, CAROL
Format: Article
Language:English
Subjects:
Animals
Arthritis
Arthritis, Experimental - drug therapy
Arthritis, Experimental - pathology
Bones
Damage
estrogen
Hormones
Incidence
inflammation
Mathematical models
Pregnancy
Rats
relaxin
Relaxin - pharmacology
Relaxin - therapeutic use
Soft tissues
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Summary:: A reduction in the incidence and severity of rheumatoid arthritis is seen in pregnant women. Relaxin, a hormone of pregnancy, has been implicated in decreased immune responsiveness. Consequently, the effects of relaxin and estradiol valerate, alone or in combination, were assessed in the development of adjuvant‐induced arthritis in the rat. Combination hormone therapy reduced adjuvant‐induced paw inflammation. Radiographic analysis of the tarsal joints showed that estradiol valerate plus relaxin treatment minimized soft tissue damage and bone changes when compared to vehicle‐treated arthritic controls. These results indicate that relaxin may be a factor in reducing inflammation during pregnancy.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1282.072