Demonstration of a High Level of Parasite Population Homology by Quantification of Plasmodium falciparum Alleles in Matched Peripheral, Placental, and Umbilical Cord Blood Samples

Plasmodium falciparum msp-1 and msp-2 genes were quantified by fragment analysis in matched placental, peripheral, and cord blood samples. In the three compartments, the multiplicity of infection values were similar, and parasite populations only partially overlapped, as reported. However, identical...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2005-06, Vol.43 (6), p.2980-2983
Main Authors: Jafari-Guemouri, Sayeh, Ndam, Nicaise Tuikue, Bertin, Gwladys, Renart, Emily, Sow, Sokhna, Le Hesran, Jean-Yves, Deloron, Philippe
Format: Article
Language:English
Subjects:
Alleles
Animals
Antigens, Protozoan - genetics
Biological and medical sciences
Blood - parasitology
Female
Fetal Blood - parasitology
Fundamental and applied biological sciences. Psychology
Humans
Infant, Newborn
Infectious diseases
Malaria, Falciparum - parasitology
Medical sciences
Merozoite Surface Protein 1 - genetics
Microbiology
Parasitology
Placenta - parasitology
Plasmodium falciparum - genetics
Plasmodium falciparum - isolation & purification
Pregnancy
Pregnancy Complications, Parasitic - parasitology
Protozoan Proteins - genetics
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Summary:Plasmodium falciparum msp-1 and msp-2 genes were quantified by fragment analysis in matched placental, peripheral, and cord blood samples. In the three compartments, the multiplicity of infection values were similar, and parasite populations only partially overlapped, as reported. However, identical alleles represented 80 to 95% of the overall parasite populations of each compartment, demonstrating much more homogenous parasite populations than previously thought.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.43.6.2980-2983.2005