Possible novel index determined by the glucose clamp test for selection of a suitable therapy for each type 2 diabetic patient

The hallmark of type 2 diabetes is insulin resistance and insufficient insulin secretion, and appropriate therapy should be selected for each patient. In this study, to establish some index to select suitable therapy for each patient, we evaluated insulin sensitivity and insulin secretion with eugly...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2005-07, Vol.69 (1), p.1-4
Main Authors: Gorogawa, Shin-ichi, Kaneto, Hideaki, Matsuhisa, Munehide, Ohtoshi, Kentaro, Kawamori, Dan, Hazama, Yoji, Yoshiuchi, Kazutomi, Yamasaki, Yoshimitsu
Format: Article
Language:English
Subjects:
Blood Glucose - metabolism
Body Mass Index
Diabetes Mellitus, Type 2 - classification
Diabetes Mellitus, Type 2 - therapy
Female
Glucose - administration & dosage
Glucose - pharmacology
Glucose Clamp Technique - methods
Glucose clamp test
Humans
Hyperglycemia
Hyperinsulinism
Insulin - blood
Insulin - metabolism
Insulin Resistance
Insulin Secretion
Male
Middle Aged
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Summary:The hallmark of type 2 diabetes is insulin resistance and insufficient insulin secretion, and appropriate therapy should be selected for each patient. In this study, to establish some index to select suitable therapy for each patient, we evaluated insulin sensitivity and insulin secretion with euglycemic hyperinsulinemic clamp and hyperglycemic clamp tests, respectively, and found that specific GIR index (GIR × IRI (90)) could be a useful marker to select suitable therapy for each type 2 diabetic patient (GIR: glucose infusion rate in euglycemic hyperinsulinemic clamp test; IRI (90): plasma insulin level 90 min after starting the hyperglycemic clamp test).
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2004.10.006