Thrombopoietin and the Hematopoietic Stem Cell

: The molecular mechanisms that underlie the favorable effects of thrombopoietin on stem cell survival, self‐renewal, and expansion are unknown. On the basis of known effects of HoxB4, HoxA9, and vascular endothelial cell growth factor on stem cells, we explored whether TPO might affect these pathwa...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2005-06, Vol.1044 (1), p.139-141
Main Author: KAUSHANSKY, KENNETH
Format: Article
Language:English
Subjects:
Animals
Endothelial cells
Growth factors
hematopoietic stem cells
Hematopoietic Stem Cells - metabolism
Hox genes
Humans
Localization
Olefinic thermoplastic elastomers
Pathways
Position (location)
Stem cells
Survival
thrombopoietin
Thrombopoietin - metabolism
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Summary:: The molecular mechanisms that underlie the favorable effects of thrombopoietin on stem cell survival, self‐renewal, and expansion are unknown. On the basis of known effects of HoxB4, HoxA9, and vascular endothelial cell growth factor on stem cells, we explored whether TPO might affect these pathways. We found that TPO enhances the transcription of HoxB4, induces the nuclear localization of HoxA9, and upregulates VEGF expression by reducing the ubiquination of hypoxia inducible factor.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1349.018