New “Hogs” in Hedgehog Transport and Signal Reception

A recent paper in Cell (Yao et al., 2006) and two papers in Developmental Cell (Tenzen et al., 2006; Zhang et al., 2006) identify a new receptor component for Hedgehog, a key morphogen in embryonic development. Many other proteins that bind to Hedgehog in the extracellular matrix or on the cell surf...

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Bibliographic Details
Published in:Cell 2006-05, Vol.125 (3), p.435-438
Main Authors: Wilson, Christopher W., Chuang, Pao-Tien
Format: Article
Language:English
Subjects:
Animals
Embryonic Development - physiology
Hedgehog Proteins
Heparan Sulfate Proteoglycans - metabolism
Humans
Macromolecular Substances - metabolism
Patched Receptors
Protein Binding - physiology
Protein Transport - physiology
Receptors, Cell Surface - genetics
Receptors, Cell Surface - metabolism
Signal Transduction - physiology
Trans-Activators - genetics
Trans-Activators - metabolism
Trans-Activators - secretion
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Summary:A recent paper in Cell (Yao et al., 2006) and two papers in Developmental Cell (Tenzen et al., 2006; Zhang et al., 2006) identify a new receptor component for Hedgehog, a key morphogen in embryonic development. Many other proteins that bind to Hedgehog in the extracellular matrix or on the cell surface have been identified. In light of these recent discoveries, we discuss how these factors control the stability, transport, reception, and availability of Hedgehog in modulating Hedgehog-mediated responses.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2006.04.016