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The changes in T lymphocyte subsets following periodontal treatment in patients with chronic periodontitis
Objective: The aim of this study was to determine whether there was any change in T‐lymphocyte subsets in patients with chronic periodontitis after applying different periodontal treatment methods. Patients and methods: Twenty‐four patients with chronic periodontitis were included in the study. In...
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| Published in: | Journal of periodontal research 2006-06, Vol.41 (3), p.165-170 |
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| cites | cdi_FETCH-LOGICAL-c4655-a1252a70553ecc50f4b007188582f46dd5ff875a7824deae6ac7d8798a02a143 |
| container_end_page | 170 |
| container_issue | 3 |
| container_start_page | 165 |
| container_title | Journal of periodontal research |
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| creator | Erciyas, Kamile Orbak, Recep Kavrut, Fahri Demir, Turgut Kaya, Hasan |
| description | Objective: The aim of this study was to determine whether there was any change in T‐lymphocyte subsets in patients with chronic periodontitis after applying different periodontal treatment methods.
Patients and methods: Twenty‐four patients with chronic periodontitis were included in the study. In every phase of the treatment (pretreatment, initial treatment, curettage and flap operations) the biopsy samples were taken from the gingival tissues at sites of chronic periodontitis. Then CD4+ and CD8+ lymphocyte and CD4+/CD8+ ratio values were determined using flow cytometry in the biopsy samples. At the same time, gingival pocket depth, Löe–Silness gingival index, and Silness–Löe plaque index scores were recorded to assess the periodontal status in patients. To determine the correlation between the clinical measurements and the laboratory results obtained before the treatment, after initial treatment, after curettage and after flap operations, we conducted an analysis using a paired t‐test.
Results: Flow cytometry findings in the patients with chronic periodontitis showed that CD4+ and CD8+ lymphocyte values before treatment were under the normal value and the CD4+/CD8+ ratio was within the normal distribution interval. The CD4+/CD8+ ratio decreased postcurettage and postflap operation. This decrease was statistically significant (p |
| doi_str_mv | 10.1111/j.1600-0765.2005.00855.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67940614</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>19440357</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4655-a1252a70553ecc50f4b007188582f46dd5ff875a7824deae6ac7d8798a02a143</originalsourceid><addsrcrecordid>eNqNkUGP0zAQhS0EYsvCX0C-wC1h4tixK3FBq91CtQItqoTExXIdZ-vixMF21fbf49Bqe11fPNZ8bzx6DyFcQVnl82lbVg1AAbxhJQFgJYBgrDy8QLOnxks0AyCkqKmgV-hNjFvI74bPX6Orqmk4J6Keoe1qY7DeqOHRRGwHvMLu2I8br4_J4LhbR5Mi7rxzfm-HRzyaYH3rh6QcTsGo1JshTbpRJZvLiPc2bfLA4AerL7hNNr5Frzrlonl3vq_R6u52dfO1uP-x-Hbz5b7QtGGsUBVhRHFgrDZaM-joGoBXQjBBOtq0Les6wZnigtDWKNMozVvB50IBURWtr9HH09gx-L87E5PsbdTGOTUYv4syO0CheQZYzSmFmvEMihOog48xmE6OwfYqHGUFcspDbuVku5xsl1Me8n8e8pCl789_7Na9aS_CcwAZ-HAGVNTKdUEN2sYLxzmrOZ-4zydub505PnsBufx5m4ssL05yG5M5PMlV-JP9qDmTv74v5LKG3w_Lh6Vc1P8A_se2kQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19440357</pqid></control><display><type>article</type><title>The changes in T lymphocyte subsets following periodontal treatment in patients with chronic periodontitis</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Erciyas, Kamile ; Orbak, Recep ; Kavrut, Fahri ; Demir, Turgut ; Kaya, Hasan</creator><creatorcontrib>Erciyas, Kamile ; Orbak, Recep ; Kavrut, Fahri ; Demir, Turgut ; Kaya, Hasan</creatorcontrib><description>Objective: The aim of this study was to determine whether there was any change in T‐lymphocyte subsets in patients with chronic periodontitis after applying different periodontal treatment methods.
Patients and methods: Twenty‐four patients with chronic periodontitis were included in the study. In every phase of the treatment (pretreatment, initial treatment, curettage and flap operations) the biopsy samples were taken from the gingival tissues at sites of chronic periodontitis. Then CD4+ and CD8+ lymphocyte and CD4+/CD8+ ratio values were determined using flow cytometry in the biopsy samples. At the same time, gingival pocket depth, Löe–Silness gingival index, and Silness–Löe plaque index scores were recorded to assess the periodontal status in patients. To determine the correlation between the clinical measurements and the laboratory results obtained before the treatment, after initial treatment, after curettage and after flap operations, we conducted an analysis using a paired t‐test.
Results: Flow cytometry findings in the patients with chronic periodontitis showed that CD4+ and CD8+ lymphocyte values before treatment were under the normal value and the CD4+/CD8+ ratio was within the normal distribution interval. The CD4+/CD8+ ratio decreased postcurettage and postflap operation. This decrease was statistically significant (p < 0.001). The CD4+ and CD8+ lymphocyte values were increased postcurettage and postflap operation. This increase was also statistically significant (p < 0.001).
Conclusions: These findings suggest that local immune response was poor in the patients with chronic periodontitis. CD4+ and CD8+ T‐lymphocytes could play a significant role in chronic periodontitis pathobiology.</description><identifier>ISSN: 0022-3484</identifier><identifier>EISSN: 1600-0765</identifier><identifier>DOI: 10.1111/j.1600-0765.2005.00855.x</identifier><identifier>PMID: 16677283</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Biological and medical sciences ; Biopsy ; CD4 Lymphocyte Count ; CD4-CD8 Ratio ; CD8-Positive T-Lymphocytes - pathology ; cell immunity ; Chronic Disease ; chronic periodontitis ; Dental Plaque Index ; Dental Scaling ; Dentistry ; Facial bones, jaws, teeth, parodontium: diseases, semeiology ; Female ; Flow Cytometry ; Follow-Up Studies ; Gingiva - immunology ; Gingival Pocket - immunology ; Humans ; Lymphocyte Count ; Male ; Medical sciences ; Middle Aged ; Non tumoral diseases ; Otorhinolaryngology. Stomatology ; Periodontal Index ; periodontal treatment ; Periodontitis - immunology ; Periodontitis - therapy ; Root Planing ; Subgingival Curettage ; Surgical Flaps ; T-Lymphocyte Subsets - pathology</subject><ispartof>Journal of periodontal research, 2006-06, Vol.41 (3), p.165-170</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4655-a1252a70553ecc50f4b007188582f46dd5ff875a7824deae6ac7d8798a02a143</citedby><cites>FETCH-LOGICAL-c4655-a1252a70553ecc50f4b007188582f46dd5ff875a7824deae6ac7d8798a02a143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17753773$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16677283$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Erciyas, Kamile</creatorcontrib><creatorcontrib>Orbak, Recep</creatorcontrib><creatorcontrib>Kavrut, Fahri</creatorcontrib><creatorcontrib>Demir, Turgut</creatorcontrib><creatorcontrib>Kaya, Hasan</creatorcontrib><title>The changes in T lymphocyte subsets following periodontal treatment in patients with chronic periodontitis</title><title>Journal of periodontal research</title><addtitle>J Periodontal Res</addtitle><description>Objective: The aim of this study was to determine whether there was any change in T‐lymphocyte subsets in patients with chronic periodontitis after applying different periodontal treatment methods.
Patients and methods: Twenty‐four patients with chronic periodontitis were included in the study. In every phase of the treatment (pretreatment, initial treatment, curettage and flap operations) the biopsy samples were taken from the gingival tissues at sites of chronic periodontitis. Then CD4+ and CD8+ lymphocyte and CD4+/CD8+ ratio values were determined using flow cytometry in the biopsy samples. At the same time, gingival pocket depth, Löe–Silness gingival index, and Silness–Löe plaque index scores were recorded to assess the periodontal status in patients. To determine the correlation between the clinical measurements and the laboratory results obtained before the treatment, after initial treatment, after curettage and after flap operations, we conducted an analysis using a paired t‐test.
Results: Flow cytometry findings in the patients with chronic periodontitis showed that CD4+ and CD8+ lymphocyte values before treatment were under the normal value and the CD4+/CD8+ ratio was within the normal distribution interval. The CD4+/CD8+ ratio decreased postcurettage and postflap operation. This decrease was statistically significant (p < 0.001). The CD4+ and CD8+ lymphocyte values were increased postcurettage and postflap operation. This increase was also statistically significant (p < 0.001).
Conclusions: These findings suggest that local immune response was poor in the patients with chronic periodontitis. CD4+ and CD8+ T‐lymphocytes could play a significant role in chronic periodontitis pathobiology.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>CD4 Lymphocyte Count</subject><subject>CD4-CD8 Ratio</subject><subject>CD8-Positive T-Lymphocytes - pathology</subject><subject>cell immunity</subject><subject>Chronic Disease</subject><subject>chronic periodontitis</subject><subject>Dental Plaque Index</subject><subject>Dental Scaling</subject><subject>Dentistry</subject><subject>Facial bones, jaws, teeth, parodontium: diseases, semeiology</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Follow-Up Studies</subject><subject>Gingiva - immunology</subject><subject>Gingival Pocket - immunology</subject><subject>Humans</subject><subject>Lymphocyte Count</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Non tumoral diseases</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Periodontal Index</subject><subject>periodontal treatment</subject><subject>Periodontitis - immunology</subject><subject>Periodontitis - therapy</subject><subject>Root Planing</subject><subject>Subgingival Curettage</subject><subject>Surgical Flaps</subject><subject>T-Lymphocyte Subsets - pathology</subject><issn>0022-3484</issn><issn>1600-0765</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqNkUGP0zAQhS0EYsvCX0C-wC1h4tixK3FBq91CtQItqoTExXIdZ-vixMF21fbf49Bqe11fPNZ8bzx6DyFcQVnl82lbVg1AAbxhJQFgJYBgrDy8QLOnxks0AyCkqKmgV-hNjFvI74bPX6Orqmk4J6Keoe1qY7DeqOHRRGwHvMLu2I8br4_J4LhbR5Mi7rxzfm-HRzyaYH3rh6QcTsGo1JshTbpRJZvLiPc2bfLA4AerL7hNNr5Frzrlonl3vq_R6u52dfO1uP-x-Hbz5b7QtGGsUBVhRHFgrDZaM-joGoBXQjBBOtq0Les6wZnigtDWKNMozVvB50IBURWtr9HH09gx-L87E5PsbdTGOTUYv4syO0CheQZYzSmFmvEMihOog48xmE6OwfYqHGUFcspDbuVku5xsl1Me8n8e8pCl789_7Na9aS_CcwAZ-HAGVNTKdUEN2sYLxzmrOZ-4zydub505PnsBufx5m4ssL05yG5M5PMlV-JP9qDmTv74v5LKG3w_Lh6Vc1P8A_se2kQ</recordid><startdate>200606</startdate><enddate>200606</enddate><creator>Erciyas, Kamile</creator><creator>Orbak, Recep</creator><creator>Kavrut, Fahri</creator><creator>Demir, Turgut</creator><creator>Kaya, Hasan</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200606</creationdate><title>The changes in T lymphocyte subsets following periodontal treatment in patients with chronic periodontitis</title><author>Erciyas, Kamile ; Orbak, Recep ; Kavrut, Fahri ; Demir, Turgut ; Kaya, Hasan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4655-a1252a70553ecc50f4b007188582f46dd5ff875a7824deae6ac7d8798a02a143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>CD4 Lymphocyte Count</topic><topic>CD4-CD8 Ratio</topic><topic>CD8-Positive T-Lymphocytes - pathology</topic><topic>cell immunity</topic><topic>Chronic Disease</topic><topic>chronic periodontitis</topic><topic>Dental Plaque Index</topic><topic>Dental Scaling</topic><topic>Dentistry</topic><topic>Facial bones, jaws, teeth, parodontium: diseases, semeiology</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Follow-Up Studies</topic><topic>Gingiva - immunology</topic><topic>Gingival Pocket - immunology</topic><topic>Humans</topic><topic>Lymphocyte Count</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Non tumoral diseases</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Periodontal Index</topic><topic>periodontal treatment</topic><topic>Periodontitis - immunology</topic><topic>Periodontitis - therapy</topic><topic>Root Planing</topic><topic>Subgingival Curettage</topic><topic>Surgical Flaps</topic><topic>T-Lymphocyte Subsets - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Erciyas, Kamile</creatorcontrib><creatorcontrib>Orbak, Recep</creatorcontrib><creatorcontrib>Kavrut, Fahri</creatorcontrib><creatorcontrib>Demir, Turgut</creatorcontrib><creatorcontrib>Kaya, Hasan</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of periodontal research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Erciyas, Kamile</au><au>Orbak, Recep</au><au>Kavrut, Fahri</au><au>Demir, Turgut</au><au>Kaya, Hasan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The changes in T lymphocyte subsets following periodontal treatment in patients with chronic periodontitis</atitle><jtitle>Journal of periodontal research</jtitle><addtitle>J Periodontal Res</addtitle><date>2006-06</date><risdate>2006</risdate><volume>41</volume><issue>3</issue><spage>165</spage><epage>170</epage><pages>165-170</pages><issn>0022-3484</issn><eissn>1600-0765</eissn><abstract>Objective: The aim of this study was to determine whether there was any change in T‐lymphocyte subsets in patients with chronic periodontitis after applying different periodontal treatment methods.
Patients and methods: Twenty‐four patients with chronic periodontitis were included in the study. In every phase of the treatment (pretreatment, initial treatment, curettage and flap operations) the biopsy samples were taken from the gingival tissues at sites of chronic periodontitis. Then CD4+ and CD8+ lymphocyte and CD4+/CD8+ ratio values were determined using flow cytometry in the biopsy samples. At the same time, gingival pocket depth, Löe–Silness gingival index, and Silness–Löe plaque index scores were recorded to assess the periodontal status in patients. To determine the correlation between the clinical measurements and the laboratory results obtained before the treatment, after initial treatment, after curettage and after flap operations, we conducted an analysis using a paired t‐test.
Results: Flow cytometry findings in the patients with chronic periodontitis showed that CD4+ and CD8+ lymphocyte values before treatment were under the normal value and the CD4+/CD8+ ratio was within the normal distribution interval. The CD4+/CD8+ ratio decreased postcurettage and postflap operation. This decrease was statistically significant (p < 0.001). The CD4+ and CD8+ lymphocyte values were increased postcurettage and postflap operation. This increase was also statistically significant (p < 0.001).
Conclusions: These findings suggest that local immune response was poor in the patients with chronic periodontitis. CD4+ and CD8+ T‐lymphocytes could play a significant role in chronic periodontitis pathobiology.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16677283</pmid><doi>10.1111/j.1600-0765.2005.00855.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of periodontal research, 2006-06, Vol.41 (3), p.165-170 |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adult Biological and medical sciences Biopsy CD4 Lymphocyte Count CD4-CD8 Ratio CD8-Positive T-Lymphocytes - pathology cell immunity Chronic Disease chronic periodontitis Dental Plaque Index Dental Scaling Dentistry Facial bones, jaws, teeth, parodontium: diseases, semeiology Female Flow Cytometry Follow-Up Studies Gingiva - immunology Gingival Pocket - immunology Humans Lymphocyte Count Male Medical sciences Middle Aged Non tumoral diseases Otorhinolaryngology. Stomatology Periodontal Index periodontal treatment Periodontitis - immunology Periodontitis - therapy Root Planing Subgingival Curettage Surgical Flaps T-Lymphocyte Subsets - pathology |
| title | The changes in T lymphocyte subsets following periodontal treatment in patients with chronic periodontitis |
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