Recovery after a traumatic brain injury depends on diurnal variations Effect of cystatin C

• Published in: Neuroscience letters 2006-05, Vol.400 (1-2), p.21-24
• Main Authors: MARTINEZ-VARGAS, Marina, GONZALEZ-RIVERA, Ruben, SOTO-NUNEZ, Maribel, CISNEROS-MARTINEZ, Marina, HUERTA-SAQUERO, Alejandro, MORALES-GOMEZ, Julio, MOLINA-GUARNEROS, Juan, NAVARRO, Luz
• Format: Article
• Language: English
• Subjects: Analysis of Variance; Animals; Biological and medical sciences; Brain Injuries - drug therapy; Brain Injuries - physiopathology; Circadian Rhythm; Cystatin C; Cystatins - administration & dosage; Disease Models, Animal; Drug Administration Schedule; Injuries of the nervous system and the skull. Diseases due to physical agents; Male; Medical sciences; Neuroprotective Agents - administration & dosage; Rats; Rats, Wistar; Recovery of Function - drug effects; Trauma Severity Indices; Traumas. Diseases due to physical agents
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/j.neulet.2006.02.010

Many studies indicate that the hour of the day at which the onset of stroke occurs is very important in patient recovery. Furthermore, multiple studies have been conducted which show that ischemia in rats produces different magnitudes of injury depending on the hour of the day at which it was induced. Using a traumatic brain injury (TBI) model, we analyzed the effect of the time of day on the recovery of rats and obtained a higher survival rate if TBI was induced at 01:00 h as compared with TBI induced at 13:00 h. We also analyzed the effect of the protease inhibitor cystatin C (CC) on the recovery of rats from TBI and found that it increased mortality and bleeding, and that these effects were more pronounced at 13:00 h.