Inflammation of craniofacial muscle induces widespread mechanical allodynia

The modulation of behavioral responses evoked by local and distant nociceptive stimuli following a discrete somatic injection of complete Freund's adjuvant (CFA) was examined in rats. Inflammation of one craniofacial muscle evoked mechanical allodynia not only in the region of inflammation but...

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Bibliographic Details
Published in:Neuroscience letters 2006-05, Vol.399 (3), p.249-254
Main Authors: Ambalavanar, Ranjinidevi, Moutanni, Aicha, Dessem, Dean
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Biological and medical sciences
Facial Muscles - physiopathology
Fibromyalgia
Freund's Adjuvant
Functional Laterality
Fundamental and applied biological sciences. Psychology
Hyperalgesia - etiology
Hyperalgesia - physiopathology
Inflammation - chemically induced
Inflammation - complications
Inflammation - physiopathology
Male
Muscle
Musculoskeletal disorders
Myalgia
Nociception
Pain
Pain Measurement - methods
Pain Threshold - physiology
Physical Stimulation - methods
Rats
Rats, Sprague-Dawley
Somesthesis and somesthetic pathways (proprioception, exteroception, nociception)
interoception
electrolocation. Sensory receptors
Time Factors
Vertebrates: nervous system and sense organs
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Summary:The modulation of behavioral responses evoked by local and distant nociceptive stimuli following a discrete somatic injection of complete Freund's adjuvant (CFA) was examined in rats. Inflammation of one craniofacial muscle evoked mechanical allodynia not only in the region of inflammation but also secondary mechanical allodynia in the contralateral head, ipsilateral hindpaw, and contralateral hindpaw. In contrast to this, CFA-induced inflammation of either the hindpaw or gastrocnemius muscle evoked mechanical allodynia restricted to the hindlimb region. The widespread modulation of nocifensive behavior evoked by inflammation of deep craniofacial tissue found in this study resembles the widespread deep tissue pain reported in fibromyalgia, whiplash injury and some temporomandibular disorders and thus may provide insight into the mechanisms of these musculoskeletal pathologies.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2006.02.003