Ion-Channel Noise Places Limits on the Miniaturization of the Brain’s Wiring

The action potential (AP) is transmitted by the concerted action of voltage-gated ion channels. Thermodynamic fluctuations in channel proteins produce probabilistic gating behavior, causing channel noise. Miniaturizing signaling systems increases susceptibility to noise, and with many cortical, cere...

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Bibliographic Details
Published in:Current biology 2005-06, Vol.15 (12), p.1143-1149
Main Authors: Faisal, A. Aldo, White, John A., Laughlin, Simon B.
Format: Article
Language:English
Subjects:
Animals
Axons - physiology
Biophysical Phenomena
Biophysics
Brain - physiology
Cerebral Cortex - anatomy & histology
Cerebral Cortex - physiology
Ion Channels - metabolism
Mammals
Models, Neurological
Stochastic Processes
Synaptic Transmission - physiology
Temperature
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Summary:The action potential (AP) is transmitted by the concerted action of voltage-gated ion channels. Thermodynamic fluctuations in channel proteins produce probabilistic gating behavior, causing channel noise. Miniaturizing signaling systems increases susceptibility to noise, and with many cortical, cerebellar, and peripheral axons
ISSN:0960-9822
1879-0445
DOI:10.1016/j.cub.2005.05.056