Sox group E gene expression distinguishes different types and maturational stages of glial cells in developing chick and mouse

The SoxE genes, Sox8, Sox9 and Sox10, have been shown to modulate glial specification and differentiation in the peripheral nervous system and spinal cord. However, little is known of their expression during brain development. We have therefore analyzed their expression in developing brain, focused...

Full description

Saved in:
Bibliographic Details
Published in:Brain research. Developmental brain research 2005-06, Vol.157 (2), p.209-213
Main Authors: Kordes, Uwe, Cheng, Yi-Chuan, Scotting, Paul J.
Format: Article
Language:English
Subjects:
Animals
Astrocyte
Astrocytes - cytology
Astrocytes - metabolism
Basic Helix-Loop-Helix Transcription Factors
Cell Differentiation - physiology
Cell Lineage - physiology
Cerebellum
Cerebellum - cytology
Cerebellum - embryology
Cerebellum - metabolism
Chick Embryo
DNA-Binding Proteins - genetics
Gene Expression Regulation, Developmental - physiology
High Mobility Group Proteins - genetics
Mice
Neoplasm Proteins - genetics
Nerve Tissue Proteins - genetics
Neuroglia - cytology
Neuroglia - metabolism
Oligodendrocyte
Oligodendrocyte Transcription Factor 2
Oligodendroglia - cytology
Oligodendroglia - metabolism
RNA, Messenger - metabolism
Sox10
Sox8
Sox9
SOX9 Transcription Factor
SOXE Transcription Factors
Species Specificity
Stem Cells - cytology
Stem Cells - metabolism
Time Factors
Transcription Factors - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The SoxE genes, Sox8, Sox9 and Sox10, have been shown to modulate glial specification and differentiation in the peripheral nervous system and spinal cord. However, little is known of their expression during brain development. We have therefore analyzed their expression in developing brain, focused on the cerebellum. In situ hybridization showed a striking degree of temporo-spatial variation in their expression in different glial lineages in both chick and mouse. Sox8 appeared both in oligodendrocytes and astrocytes, Sox9 was more abundant in astrocytes and Sox10 was restricted to later stages of oligodendrocyte development.
ISSN:0165-3806
DOI:10.1016/j.devbrainres.2005.03.009