The molecular physiology and pathology of fibrin structure/function

The formation of a fibrin clot is a pivotal event in atherothrombotic vascular disease and there is mounting evidence that the structure of clots is of importance in the development of disease. This review describes the crucial events in the formation and dissolution of a clot, with particular focus...

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Bibliographic Details
Published in:Blood reviews 2005-09, Vol.19 (5), p.275-288
Main Authors: Standeven, Kristina F., Ariëns, Robert A.S., Grant, Peter J.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood Coagulation - physiology
Environment
Factor XIII
Factor XIIIa - chemistry
Factor XIIIa - physiology
Fibrin
Fibrin - chemistry
Fibrin - physiology
Fibrin structure
Fibrinogen
Fibrinogen - physiology
Genetic
Haemostasis
Hematologic and hematopoietic diseases
Humans
Medical sciences
Structure-Activity Relationship
Thrombosis
Thrombosis - blood
Vascular disease
Vascular Diseases - blood
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Summary:The formation of a fibrin clot is a pivotal event in atherothrombotic vascular disease and there is mounting evidence that the structure of clots is of importance in the development of disease. This review describes the crucial events in the formation and dissolution of a clot, with particular focus on genetic and environmental factors that have been identified as determinants of fibrin structure in vivo, and discusses the substantiation of the relationship between fibrin structure and disease in conjunction with a review of the current literature.
ISSN:0268-960X
1532-1681
DOI:10.1016/j.blre.2005.01.003