Relationship between changes in thyroid hormone level and severity of the postoperative course in neonates undergoing open-heart surgery

• Published in: Pediatric anesthesia 2006-05, Vol.16 (5), p.538-542
• Main Authors: DAGAN, OVADIA, VIDNE, BERNARDO, JOSEFSBERG, ZEEV, PHILLIP, MOSHE, STRICH, DAVID, EREZ, ELDAD
• Format: Article
• Language: English
• Subjects: Anesthesia; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Biomarkers; Cardiac Surgical Procedures; eruthyroid sick syndrome; Euthyroid Sick Syndromes - mortality; Heart Defects, Congenital - surgery; Heart-Assist Devices; Hospital Mortality; Humans; Infant, Newborn; inotropic support; Medical sciences; neonate; open-heart surgery; Postoperative Complications - metabolism; Postoperative Complications - mortality; Predictive Value of Tests; Respiration, Artificial; Risk; Thyroid Function Tests; Thyroid Hormones - metabolism; Thyroxine - blood
• ISSN: 1155-5645; 1460-9592
• DOI: 10.1111/j.1460-9592.2005.01808.x

Summary Background:  Our aim was to determine whether the changes in thyroid function after open‐heart surgery in neonates depend on the postoperative course. Methods:  Twenty neonates undergoing open‐heart surgery for congenital heart disease were prospectively studied in the cardiac intensive care unit of a university‐affiliated children's hospital. The patients were divided into two groups by level of inotropic support (high or mild). Results:  The groups were similar in age, bypass time and ultrafiltration volume. In both groups, there was a significant reduction in levels of thyroid‐stimulating hormone and FT4 at 24 h postoperatively. However, in the high inotropic support group, FT4 was lower for a longer time. This group also had a significantly higher score on The Pediatric Risk of Mortality (PRISM; P