Properties and characteristics of the dyes injected to assist axillary sentinel node localization in breast surgery

A review of the safety profile of dyes injected to assist in sentinel lymph node biopsy (SLNB) in breast cancer. A literature search was performed of the medline database 1966–2005 using the Ovid ® web Gateway detailing the words sentinel node, breast cancer, allergic reactions, blue dye, isosulfan...

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Bibliographic Details
Published in:European journal of surgical oncology 2006-05, Vol.32 (4), p.381-384
Main Authors: Masannat, Y., Shenoy, H., Speirs, V., Hanby, A., Horgan, K.
Format: Article
Language:English
Subjects:
Axilla
Breast cancer
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Coloring Agents - administration & dosage
Coloring Agents - chemistry
Dye
Female
Humans
Injections
Lymph node
Lymph Nodes - pathology
Lymphatic Metastasis - diagnosis
Sentinel
Sentinel Lymph Node Biopsy
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Summary:A review of the safety profile of dyes injected to assist in sentinel lymph node biopsy (SLNB) in breast cancer. A literature search was performed of the medline database 1966–2005 using the Ovid ® web Gateway detailing the words sentinel node, breast cancer, allergic reactions, blue dye, isosulfan blue, patent blue and methylene blue. There are reported side-effects from the parenteral administration of dyes, which range from minor to life threatening in severity. There are differences between the dyes as regards their effects. These aspects are discussed. Many dyes have been used for SLNB with acceptable identification rates. There are variable side-effects for each of those dyes. Further research is needed to clarify the safety profile of these dyes.
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2006.01.010