Routine pelvic lymphadenectomy in apparently early stage endometrial cancer

Controversial issues with respect to the treatment of patients with endometrial cancer include indications for lymphadenectomy and adjuvant radiotherapy. Between 1998 and 2004 all women with endometrial cancer stage I were included ( n=335). They all underwent total abdominal hysterectomy and bilate...

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Bibliographic Details
Published in:European journal of surgical oncology 2006-05, Vol.32 (4), p.450-454
Main Authors: Zuurendonk, L.D., Smit, R.A., Mol, B.W.J., Feijen, H.W.H., de Graaff, J., Sykora, D., de Winter, K.A.J., vd Wurff, A., Snijders, M.P.M.L., Kruitwagen, R.F.P.M.
Format: Article
Language:English
Subjects:
Carcinoma - radiotherapy
Carcinoma - secondary
Carcinoma - surgery
Endometrial carcinoma
Endometrial Neoplasms - pathology
Endometrial Neoplasms - radiotherapy
Endometrial Neoplasms - surgery
Female
Humans
Lymph node excision
Lymph Node Excision - methods
Lymphatic metastases
Lymphatic Metastasis
Middle Aged
Neoplasm Staging
Pelvis
Radiotherapy, Adjuvant
Retrospective Studies
Risk Factors
Survival rate
Treatment Outcome
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Summary:Controversial issues with respect to the treatment of patients with endometrial cancer include indications for lymphadenectomy and adjuvant radiotherapy. Between 1998 and 2004 all women with endometrial cancer stage I were included ( n=335). They all underwent total abdominal hysterectomy and bilateral salpingo-oöphorectomy. Two hundred and thirty-seven women also had a pelvic lymphadenectomy. When pelvic lymphadenectomy was performed, radiotherapy was administered only to patients with lymph-node metastases. Otherwise, adjuvant radiotherapy was based on the presence of risk factors. Eleven patients had lymph-node metastases. The overall absolute and relative survival-estimate at 5 years was 85.0 and 93.7%, respectively. Loco-regional recurrence was 8.5%. In the group with pelvic lymphadenectomy and negative lymph nodes these rates were 88.2, 93.9 and 5.6%, respectively. In 58 patients without any of the risk factors tumour grade III, deep myometrial invasion, or age ≥60 years, no lymph-node metastases were found. In patients with endometrial cancer FIGO stage I without risk-factors, a phenomenon which occurs in about 25% of patients with clinical stage I endometrial cancer, a lymphadenectomy can be omitted. In other patients, the debate regarding the optimal treatment will remain.
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2006.02.008