The protective effects of incadronate on inflammation and joint destruction in established rat adjuvant arthritis

The effects of a new generation bisphosphonate, incadronate, in established adjuvant arthritis rats were evaluated according to the arthritis index, hind paw volume, and radiological and histopathological examinations. Incadronate suppressed the radiological and histopathological changes of hind paw...

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Bibliographic Details
Published in:Rheumatology international 2006-06, Vol.26 (8), p.732-740
Main Authors: HONGPU ZHAO, SHANGLI LIU, DONGSHENG HUANG, QIUYU XU, SHUTO, Toshihide, IWAMOTO, Yukihide
Format: Article
Language:English
Subjects:
Animals
Arthritis
Arthritis, Experimental - diagnostic imaging
Arthritis, Experimental - drug therapy
Arthritis, Experimental - immunology
Arthritis, Experimental - pathology
Biological and medical sciences
Bone Density Conservation Agents - pharmacology
Bones, joints and connective tissue. Antiinflammatory agents
Cartilage
Diphosphonates - pharmacology
Diseases of the osteoarticular system
Dose-Response Relationship, Drug
Extremities - diagnostic imaging
Extremities - pathology
Female
Inflammation - drug therapy
Medical sciences
Miscellaneous. Osteoarticular involvement in other diseases
Osteolysis - diagnostic imaging
Osteolysis - pathology
Osteolysis - prevention & control
Pharmacology. Drug treatments
Radiography
Random Allocation
Rats
Rats, Inbred Lew
Rodents
Time Factors
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Summary:The effects of a new generation bisphosphonate, incadronate, in established adjuvant arthritis rats were evaluated according to the arthritis index, hind paw volume, and radiological and histopathological examinations. Incadronate suppressed the radiological and histopathological changes of hind paws, as well as the joint swelling in a dose-dependent manner. In contrast, the arthritis control rats showed drastic joint inflammation, marked destruction of bone and articular cartilage. The remains of articular cartilage lost Safranin O staining, and were attached with numerous TRAP-positive multinuclear cells. Some of resorption lacunas could be seen at the cartilage matrix nearby the TRAP-positive multinuclear cells. As regards the chondroprotective effects of bisphosphonates, we speculate that it is probably concerned with the inhibition of the chondroclasts. These data indicate that bisphosphonates may be a class of effective agent that can be considered for treatment of various arthritic conditions, including human rheumatoid arthritis.
ISSN:0172-8172
1437-160X
DOI:10.1007/s00296-005-0061-8