Emerging roles of TRPM6/TRPM7 channel kinase signal transduction complexes

Investigations into Drosophila mutants with impaired vision due to mutations in the transient receptor potential gene (trp) initiated a systematic search for TRP homologs in other species, finally leading to the discovery of a whole new family of plasma membrane cation channels involved in multiple...

Full description

Saved in:
Bibliographic Details
Published in:Naunyn-Schmiedeberg's archives of pharmacology 2005-04, Vol.371 (4), p.334-341
Main Authors: Chubanov, V, Mederos y Schnitzler, M, Wäring, J, Plank, A, Gudermann, T
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Drosophila
Humans
Magnesium - metabolism
Mice
Molecular Sequence Data
Phosphotransferases - genetics
Phosphotransferases - metabolism
Phosphotransferases - physiology
Protein-Serine-Threonine Kinases
Signal Transduction - physiology
TRPM Cation Channels - genetics
TRPM Cation Channels - metabolism
TRPM Cation Channels - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Investigations into Drosophila mutants with impaired vision due to mutations in the transient receptor potential gene (trp) initiated a systematic search for TRP homologs in other species, finally leading to the discovery of a whole new family of plasma membrane cation channels involved in multiple physiological processes. Among the recently discovered TRP cation channels two homologous proteins, TRPM6 and TRPM7, display unique domain compositions and biophysical properties. These remarkable genes are vital for Mg(2+) homeostasis in vertebrates and, if disrupted, lead to cell death or human disease.
ISSN:0028-1298
1432-1912
DOI:10.1007/s00210-005-1056-4