Sildenafil Citrate Improves Self‐Esteem, Confidence, and Relationships in Men with Erectile Dysfunction: Results from an International, Multi‐Center, Double‐Blind, Placebo‐Controlled Trial

Erectile dysfunction (ED) can significantly impact a man's relationships and well‐being. We assessed changes in self‐esteem, confidence, sexual relationship satisfaction, and overall relationship satisfaction in men with ED using the validated Self‐Esteem And Relationship questionnaire (SEAR)....

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Published in:Journal of sexual medicine 2006-05, Vol.3 (3), p.521-529
Main Authors: Althof, Stanley E., O'Leary, Michael P., Cappelleri, Joseph C., Hvidsten, Kyle, Stecher, Vera J., Glina, Sidney, King, Rosie, Siegel, Richard L.
Format: Article
Language:English
Subjects:
Adult
Cross-Over Studies
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Erectile Dysfunction - drug therapy
Erectile Dysfunction - psychology
Humans
Interpersonal Relations
Male
Male Erectile Disorder
Middle Aged
Oral Vasoactive Agents
Patient Satisfaction - statistics & numerical data
Penile Erection
Phosphodiesterase Inhibitors - administration & dosage
Piperazines - administration & dosage
Psychological Assessment of Sexual Dysfunction
Purines
Self Concept
Sexual Behavior - statistics & numerical data
Sildenafil Citrate
Sulfones
Surveys and Questionnaires
Treatment Outcome
Vasodilator Agents - administration & dosage
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Summary:Erectile dysfunction (ED) can significantly impact a man's relationships and well‐being. We assessed changes in self‐esteem, confidence, sexual relationship satisfaction, and overall relationship satisfaction in men with ED using the validated Self‐Esteem And Relationship questionnaire (SEAR). This was a 12‐week, double‐blind, placebo‐controlled, flexible‐dose (25, 50, 100 mg, as needed) international study of sildenafil in men ≥18 years of age in Mexico, Brazil, Australia, and Japan. The primary study outcome was change in self‐esteem from baseline to the end of treatment. Secondary study measures were changes in other SEAR components, International Index of Erectile Function (IIEF) domains, percentage of intercourse attempts that were successful, and the response to a global efficacy question at the end of treatment. Patients were well balanced for age and duration of ED (placebo = 149 and sildenafil = 151). Compared with placebo, sildenafil significantly improved self‐esteem, confidence, sexual relationship satisfaction, and overall relationship satisfaction (P 
ISSN:1743-6095
1743-6109
DOI:10.1111/j.1743-6109.2006.00234.x