Enhanced relaxation of nanoparticle-bound supercoiled DNA in X-ray radiation

A therapeutic methodology was developed based on the large X-ray absorption cross-section of gold nanoparticles at high photon energies (>81 keV). Experimental results showed that the amounts of the relaxed circular supercoiled DNA (scDNA) for gold nanoparticle-bound scDNA were more than doubled...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2005-07 (25), p.3192-3194
Main Authors: Foley, Erika A, Carter, Joshua D, Shan, Fang, Guo, Ting
Format: Article
Language:English
Subjects:
DNA, Superhelical - chemistry
Nanoparticles
X-Rays
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Summary:A therapeutic methodology was developed based on the large X-ray absorption cross-section of gold nanoparticles at high photon energies (>81 keV). Experimental results showed that the amounts of the relaxed circular supercoiled DNA (scDNA) for gold nanoparticle-bound scDNA were more than doubled compared to that for free scDNA under otherwise identical radiation conditions.
ISSN:1359-7345
1364-548X
DOI:10.1039/b503425f