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Enhanced relaxation of nanoparticle-bound supercoiled DNA in X-ray radiation
A therapeutic methodology was developed based on the large X-ray absorption cross-section of gold nanoparticles at high photon energies (>81 keV). Experimental results showed that the amounts of the relaxed circular supercoiled DNA (scDNA) for gold nanoparticle-bound scDNA were more than doubled...
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Published in: | Chemical communications (Cambridge, England) England), 2005-07 (25), p.3192-3194 |
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container_title | Chemical communications (Cambridge, England) |
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creator | Foley, Erika A Carter, Joshua D Shan, Fang Guo, Ting |
description | A therapeutic methodology was developed based on the large X-ray absorption cross-section of gold nanoparticles at high photon energies (>81 keV). Experimental results showed that the amounts of the relaxed circular supercoiled DNA (scDNA) for gold nanoparticle-bound scDNA were more than doubled compared to that for free scDNA under otherwise identical radiation conditions. |
doi_str_mv | 10.1039/b503425f |
format | article |
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language | eng |
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source | Royal Society of Chemistry: Jisc Collections: Journals Archive 1841-2007 (2019-2023) |
subjects | DNA, Superhelical - chemistry Nanoparticles X-Rays |
title | Enhanced relaxation of nanoparticle-bound supercoiled DNA in X-ray radiation |
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