TLR-Dependent Activation Stimuli Associated with Th1 Responses Confer NK Cell Stimulatory Capacity to Mouse Dendritic Cells

Dendritic cells (DCs) have an important role in the activation of NK cells that exert direct antitumor and antimicrobial effects and can influence the development of adaptive T cell responses. DCs acquire NK cell stimulatory capacity after exposure to various stimuli. In this study we investigated t...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2005-07, Vol.175 (1), p.286-292
Main Authors: Zanoni, Ivan, Foti, Maria, Ricciardi-Castagnoli, Paola, Granucci, Francesca
Format: Article
Language:English
Subjects:
Animals
Coculture Techniques
CpG Islands - immunology
Cysteine - analogs & derivatives
Cysteine - pharmacology
Dendritic Cells - drug effects
Dendritic Cells - immunology
Interferon-gamma - biosynthesis
Killer Cells, Natural - immunology
Leishmania mexicana - immunology
Lipopolysaccharides - pharmacology
Lipoproteins - pharmacology
Lymphocyte Activation
Membrane Glycoproteins - metabolism
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mycobacterium bovis - immunology
Receptors, Cell Surface - metabolism
Th1 Cells - immunology
Toll-Like Receptors
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Summary:Dendritic cells (DCs) have an important role in the activation of NK cells that exert direct antitumor and antimicrobial effects and can influence the development of adaptive T cell responses. DCs acquire NK cell stimulatory capacity after exposure to various stimuli. In this study we investigated the nature of the stimuli that confer to DCs the NK cell-activating capacity. After exposure of DCs to TLR-dependent and -independent microbial stimuli and to nonmicrobial stimuli, we evaluated the ability of activated DCs to elicit IFN-gamma production from NK cells in vitro and to promote NK cell activation in vivo. We show in this study that only TLR-dependent microbial stimuli typically associated with Th1 responses confer to DCs the ability to activate NK cells, whereas stimuli associated with Th2 responses do not have this property.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.175.1.286