Expression of Ndrg2 in the rat frontal cortex after antidepressant and electroconvulsive treatment

Although the therapeutic action of antidepressants most likely involves the regulation of serotonergic and noradrenergic signal transduction, no consensus has been reached concerning their precise molecular or cellular mechanisms of action. In the present study, we demonstrated that chronic treatmen...

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Bibliographic Details
Published in:The international journal of neuropsychopharmacology 2005-09, Vol.8 (3), p.381-389
Main Authors: Takahashi, Kou, Yamada, Misa, Ohata, Hisayuki, Momose, Kazutaka, Higuchi, Teruhiko, Honda, Kazuo, Yamada, Mitsuhiko
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Antidepressive Agents - administration & dosage
Blotting, Western - methods
Cell Line
Drug Administration Schedule
Electroshock - methods
Frontal Lobe - drug effects
Frontal Lobe - metabolism
Frontal Lobe - radiation effects
Gene Expression - drug effects
Gene Expression - radiation effects
Humans
Immunohistochemistry - methods
Male
Microarray Analysis - methods
Nerve Tissue Proteins - genetics
Nerve Tissue Proteins - metabolism
Rats
Rats, Sprague-Dawley
Reverse Transcriptase Polymerase Chain Reaction - methods
RNA, Messenger - metabolism
Transfection - methods
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Summary:Although the therapeutic action of antidepressants most likely involves the regulation of serotonergic and noradrenergic signal transduction, no consensus has been reached concerning their precise molecular or cellular mechanisms of action. In the present study, we demonstrated that chronic treatment with a tricyclic antidepressant (imipramine) and a selective serotonin reuptake inhibitor (sertraline) reduced the expression of Ndrg2 mRNA and protein in the rat frontal cortex. Ndrg2 is a member of the N-Myc downstream-regulated genes. Interestingly, repeated ECT also significantly decreased Ndrg2 expression in this region of the brain. These data suggest that Ndrg2 may be a common functional molecule that is decreased after antidepressant treatment and ECT. Although, the functional role of Ndrg2 in the central nervous system remains unclear, our findings suggest that Ndrg2 may be associated with treatment-induced adaptive neural plasticity in the brain, a chronic target of antidepressant action. In conclusion, we have identified Ndrg2 as a candidate target molecule of antidepressants and ECT.
ISSN:1461-1457
1469-5111
DOI:10.1017/S1461145705005134