Placenta Hominis Protects Osteoporosis in Ovariectomized Rats

In China, Japan, and Korea, placenta hominis extracts (PHEs) are used clinically for the treatment of osteoporosis. The anti-osteoporotic effect of PHEs was studied. The trabecular bone area and thickness in OVX rats decreased by 50% from those in sham-operated rats; these decreases were completely...

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Bibliographic Details
Published in:Immunopharmacology and immunotoxicology 2006, Vol.28 (1), p.165-173
Main Authors: Chae, H.J., Choi, K.H., Chae, S.W., Kim, H.M., Shin, T.K., Lee, G.Y., Jeong, G.S., Park, H.R., Choi, H.I., Kim, S.B., Yoo, S.K., Kim, H.R.
Format: Article
Language:English
Subjects:
Animals
Biomarkers
Biomechanical Phenomena
Body Weight - drug effects
Bone and Bones - pathology
Bone Density
Cell Count
Disease Progression
Female
Femur Neck - pathology
Humans
Osteoblast
Osteoblasts - drug effects
Osteoclast
Osteoclasts - drug effects
Osteoporosis, Postmenopausal - pathology
Osteoporosis, Postmenopausal - prevention & control
Ovariectomy
Ovariectomy (OVX)
Placenta - chemistry
Placenta - physiology
Placenta Hominis Extracts (PHEs)
Pregnancy
Rats
Rats, Sprague-Dawley
Serum Biochemistry
Tissue Extracts - chemistry
Tissue Extracts - pharmacology
Trabecular Meshwork - cytology
Trabecular Meshwork - drug effects
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Summary:In China, Japan, and Korea, placenta hominis extracts (PHEs) are used clinically for the treatment of osteoporosis. The anti-osteoporotic effect of PHEs was studied. The trabecular bone area and thickness in OVX rats decreased by 50% from those in sham-operated rats; these decreases were completely inhibited by administration of PHEs for 7 weeks. Osteoclast numbers and the osteoblast surface were enhanced in OVX rats, but PHEs had no effect on these phenomena. Serum phosphorus and alkaline phosphatase in OVX rats increased compared to those in sham-operated rats, but the increases were not affected by the administration of PHEs. Thyroxine (T4) level was stimulated in OVX rats. The extracts inhibited the T4 level in the OVX rats. These results strongly suggest that PHEs be effective in preventing the development of bone loss induced by OVX in rats.
ISSN:0892-3973
1532-2513
DOI:10.1080/08923970600626197