Cytotoxic Constituents of the Fruit Body of Daedalea dickisii

Three new lanostane triterpenoids (1, 7, 8) and five new lanostane triterpene glucosides (2−6) have been isolated from the fruit bodies of Daedalea dickinsii. Their structures were established primarily by NMR experiments, and their biological activity against HL-60 and HCT-15 cell lines was investi...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2005-06, Vol.68 (6), p.911-914
Main Authors: Yoshikawa, Kazuko, Kouso, Kazuaki, Takahashi, Jyoji, Matsuda, Akiko, Okazoe, Mina, Umeyama, Akemi, Arihara, Shigenobu
Format: Article
Language:English
Subjects:
anticarcinogenic activity
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Biological and medical sciences
cell lines
chemical structure
cytotoxicity
Daedalea
Daedalea dickisii
daedaleanic acid
daedaleaside
DNA Fragmentation
Drug Screening Assays, Antitumor
fruiting bodies
Fruiting Bodies, Fungal - chemistry
General pharmacology
glucosides
Glucosides - chemistry
Glucosides - isolation & purification
Glucosides - pharmacology
HL-60 Cells
Humans
Japan
lanostane
Lanosterol - analogs & derivatives
Lanosterol - chemistry
Lanosterol - isolation & purification
Lanosterol - pharmacology
Medical sciences
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Polyporaceae - chemistry
spectral analysis
Triterpenes - chemistry
Triterpenes - isolation & purification
Triterpenes - pharmacology
triterpenoids
Tumor Cells, Cultured
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Summary:Three new lanostane triterpenoids (1, 7, 8) and five new lanostane triterpene glucosides (2−6) have been isolated from the fruit bodies of Daedalea dickinsii. Their structures were established primarily by NMR experiments, and their biological activity against HL-60 and HCT-15 cell lines was investigated. Compounds 3−6 induced internucleosomal DNA fragmentation characteristic of apoptotic cell death in the HL-60 cell line.
ISSN:0163-3864
1520-6025
DOI:10.1021/np058024c