Indole Alkaloids and Other Constituents of Rauwolfia serpentina

From the dried roots of Rauwolfia serpentina were isolated five new indole alkaloids, N b-methylajmaline (1), N b-methylisoajmaline (2), 3-hydroxysarpagine (3), yohimbinic acid (4), isorauhimbinic acid (5), a new iridoid glucoside, 7-epiloganin (6), and a new sucrose derivative, 6‘-O-(3,4,5-trimetho...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2005-06, Vol.68 (6), p.848-852
Main Authors: Itoh, Atsuko, Kumashiro, Tomoko, Yamaguchi, Machiko, Nagakura, Naotaka, Mizushina, Yoshiyuki, Nishi, Toyoyuki, Tanahashi, Takao
Format: Article
Language:English
Subjects:
7-epiloganin
ajmaline
anticarcinogenic activity
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Biological and medical sciences
cell lines
chemical structure
cytotoxicity
Drug Screening Assays, Antitumor
General pharmacology
glomeratose
glucosides
HL-60 Cells
Humans
hydroxysarpagine
indole alkaloids
Indole Alkaloids - chemistry
Indole Alkaloids - isolation & purification
Indole Alkaloids - pharmacology
isoajmaline
isoranuhimbinic acid
Medical sciences
methylajmaline
methylisoajmaline
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Roots - chemistry
Plants, Medicinal - chemistry
Rauvolfia serpentina
Rauwolfia - chemistry
spectral analysis
Thailand
yohimbinic acid
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Summary:From the dried roots of Rauwolfia serpentina were isolated five new indole alkaloids, N b-methylajmaline (1), N b-methylisoajmaline (2), 3-hydroxysarpagine (3), yohimbinic acid (4), isorauhimbinic acid (5), a new iridoid glucoside, 7-epiloganin (6), and a new sucrose derivative, 6‘-O-(3,4,5-trimethoxybenzoyl)glomeratose A (7), together with 20 known compounds. The structures of the new compounds were determined by spectroscopic and chemical means. The inhibitory activities of the selected alkaloids on topoisomerase I and II and their cytotoxicity against the human promyelocytic leukemia (HL-60) cell lines were assessed.
ISSN:0163-3864
1520-6025
DOI:10.1021/np058007n