Aldosterone nongenomically worsens ischemia via protein kinase C-dependent pathways in hypoperfused canine hearts

Rapid nongenomic actions of aldosterone independent of mineralocorticoid receptors (MRs) on vascular tone are divergent. Until now, the rapid nongenomic actions of aldosterone on vascular tone of coronary artery and cardiac function in the in vivo ischemic hearts were not still fully estimated. Furt...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2005-07, Vol.46 (1), p.113-117
Main Authors: Fujita, Masashi, Minamino, Tetsuo, Asanuma, Hiroshi, Sanada, Shoji, Hirata, Akio, Wakeno, Masakatsu, Myoishi, Masafumi, Okuda, Hiroko, Ogai, Akiko, Okada, Ken-ichiro, Tsukamoto, Osamu, Koyama, Hidekazu, Hori, Masatsugu, Kitakaze, Masafumi
Format: Article
Language:English
Subjects:
Aldosterone - administration & dosage
Aldosterone - pharmacology
Animals
Coronary Circulation - drug effects
Coronary Vessels
Dogs
Enzyme Activation - drug effects
Heart - drug effects
Heart - physiopathology
Hemodynamics - drug effects
Injections, Intra-Arterial
Myocardial Contraction
Myocardial Ischemia - physiopathology
Myocardium - enzymology
Protein Kinase C - metabolism
Vasoconstriction
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Summary:Rapid nongenomic actions of aldosterone independent of mineralocorticoid receptors (MRs) on vascular tone are divergent. Until now, the rapid nongenomic actions of aldosterone on vascular tone of coronary artery and cardiac function in the in vivo ischemic hearts were not still fully estimated. Furthermore, although aldosterone can modulate protein kinase C (PKC) activity, there is no clear consensus whether PKC is involved in the nongenomic actions of aldosterone on the ischemic hearts. In open chest dogs, the selective infusion of aldosterone into the left anterior descending coronary artery (LAD) reduced coronary blood flow (CBF) in the nonischemic hearts in a dose-dependent manner. Also, in the ischemic state that CBF was decreased to 33% of the baseline, the intracoronary administration of aldosterone (0.1 nmol/L) rapidly decreased CBF (37.4+/-3.8 to 19.3+/-5.2 mL/100 g/min; P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.hyp.0000171184.84077.80