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Relation of High-Sensitivity C-Reactive Protein, Interleukin-6, Tumor Necrosis Factor-Alpha, and Fibrinogen to Abdominal Adipose Tissue, Blood Pressure, and Cholesterol and Triglyceride Levels in Healthy Postmenopausal Women

The associations of inflammatory markers (high-sensitivity C-reactive protein [hs-CRP], interleukin-6 [IL-6], tumor necrosis factor-α, and fibrinogen) with anthropometric and metabolic variables were examined in a sample of 112 postmenopausal women not receiving hormone therapy. Body fat distributio...

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Bibliographic Details
Published in:The American journal of cardiology 2005-07, Vol.96 (1), p.92-97
Main Authors: Piché, Marie-Ève, Lemieux, Simone, Weisnagel, Stanley John, Corneau, Louise, Nadeau, André, Bergeron, Jean
Format: Article
Language:English
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Summary:The associations of inflammatory markers (high-sensitivity C-reactive protein [hs-CRP], interleukin-6 [IL-6], tumor necrosis factor-α, and fibrinogen) with anthropometric and metabolic variables were examined in a sample of 112 postmenopausal women not receiving hormone therapy. Body fat distribution was measured by computed tomography, and insulin sensitivity was determined by an euglycemic-hyperinsulinemic clamp. hs-CRP (0.10 ≤ r 2 ≤0.37) and IL-6 (0.06 ≤ r 2 ≤0.31) were significantly associated with anthropometric and metabolic variables, including visceral and subcutaneous adipose tissue, systolic and diastolic blood pressure, triglycerides, high-density lipoprotein (HDL) cholesterol, and insulin sensitivity (p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2005.02.051