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Relation of High-Sensitivity C-Reactive Protein, Interleukin-6, Tumor Necrosis Factor-Alpha, and Fibrinogen to Abdominal Adipose Tissue, Blood Pressure, and Cholesterol and Triglyceride Levels in Healthy Postmenopausal Women
The associations of inflammatory markers (high-sensitivity C-reactive protein [hs-CRP], interleukin-6 [IL-6], tumor necrosis factor-α, and fibrinogen) with anthropometric and metabolic variables were examined in a sample of 112 postmenopausal women not receiving hormone therapy. Body fat distributio...
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Published in: | The American journal of cardiology 2005-07, Vol.96 (1), p.92-97 |
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creator | Piché, Marie-Ève Lemieux, Simone Weisnagel, Stanley John Corneau, Louise Nadeau, André Bergeron, Jean |
description | The associations of inflammatory markers (high-sensitivity C-reactive protein [hs-CRP], interleukin-6 [IL-6], tumor necrosis factor-α, and fibrinogen) with anthropometric and metabolic variables were examined in a sample of 112 postmenopausal women not receiving hormone therapy. Body fat distribution was measured by computed tomography, and insulin sensitivity was determined by an euglycemic-hyperinsulinemic clamp. hs-CRP (0.10 ≤ r
2 ≤0.37) and IL-6 (0.06 ≤ r
2 ≤0.31) were significantly associated with anthropometric and metabolic variables, including visceral and subcutaneous adipose tissue, systolic and diastolic blood pressure, triglycerides, high-density lipoprotein (HDL) cholesterol, and insulin sensitivity (p |
doi_str_mv | 10.1016/j.amjcard.2005.02.051 |
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2 ≤0.37) and IL-6 (0.06 ≤ r
2 ≤0.31) were significantly associated with anthropometric and metabolic variables, including visceral and subcutaneous adipose tissue, systolic and diastolic blood pressure, triglycerides, high-density lipoprotein (HDL) cholesterol, and insulin sensitivity (p <0.05). Women with greater hs-CRP concentrations showed deterioration in their metabolic risk profiles, including abdominal obesity, greater triglyceride and lower HDL cholesterol concentrations, and lower insulin sensitivity compared with women with lower hs-CRP levels. Fifty-nine percent of women with high hs-CRP concentrations had the metabolic syndrome as recently defined by the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. After adjustment for visceral adipose tissue, most of the differences in the plasma lipid-lipoprotein profile were eliminated between women with high hs-CRP levels and women with low hs-CRP levels, whereas some differences in blood pressure variables, insulin sensitivity, and inflammatory markers (IL-6 and fibrinogen) remained significant. In conclusion, these results suggest that increased visceral adipose tissue levels appear to be a determinant covariable of the association between high hs-CRP concentrations and alteration in the metabolic profile.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2005.02.051</identifier><identifier>PMID: 15979442</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adipose Tissue ; Aged ; Biological and medical sciences ; Biomarkers - blood ; Blood Pressure ; Body Composition ; C-Reactive Protein - analysis ; Cardiology. Vascular system ; Cholesterol - blood ; Fibrinogen - analysis ; Humans ; Inflammation ; Interleukin-6 - blood ; Male ; Medical sciences ; Middle Aged ; Postmenopause ; Triglycerides - blood ; Tumor Necrosis Factor-alpha - analysis ; Viscera</subject><ispartof>The American journal of cardiology, 2005-07, Vol.96 (1), p.92-97</ispartof><rights>2005 Elsevier Inc.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-338939c91e0a3a6cb7337ef53d1adda70cdd67a1a269bbdeab644d0924cd19493</citedby><cites>FETCH-LOGICAL-c459t-338939c91e0a3a6cb7337ef53d1adda70cdd67a1a269bbdeab644d0924cd19493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16945118$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15979442$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Piché, Marie-Ève</creatorcontrib><creatorcontrib>Lemieux, Simone</creatorcontrib><creatorcontrib>Weisnagel, Stanley John</creatorcontrib><creatorcontrib>Corneau, Louise</creatorcontrib><creatorcontrib>Nadeau, André</creatorcontrib><creatorcontrib>Bergeron, Jean</creatorcontrib><title>Relation of High-Sensitivity C-Reactive Protein, Interleukin-6, Tumor Necrosis Factor-Alpha, and Fibrinogen to Abdominal Adipose Tissue, Blood Pressure, and Cholesterol and Triglyceride Levels in Healthy Postmenopausal Women</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>The associations of inflammatory markers (high-sensitivity C-reactive protein [hs-CRP], interleukin-6 [IL-6], tumor necrosis factor-α, and fibrinogen) with anthropometric and metabolic variables were examined in a sample of 112 postmenopausal women not receiving hormone therapy. Body fat distribution was measured by computed tomography, and insulin sensitivity was determined by an euglycemic-hyperinsulinemic clamp. hs-CRP (0.10 ≤ r
2 ≤0.37) and IL-6 (0.06 ≤ r
2 ≤0.31) were significantly associated with anthropometric and metabolic variables, including visceral and subcutaneous adipose tissue, systolic and diastolic blood pressure, triglycerides, high-density lipoprotein (HDL) cholesterol, and insulin sensitivity (p <0.05). Women with greater hs-CRP concentrations showed deterioration in their metabolic risk profiles, including abdominal obesity, greater triglyceride and lower HDL cholesterol concentrations, and lower insulin sensitivity compared with women with lower hs-CRP levels. Fifty-nine percent of women with high hs-CRP concentrations had the metabolic syndrome as recently defined by the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. After adjustment for visceral adipose tissue, most of the differences in the plasma lipid-lipoprotein profile were eliminated between women with high hs-CRP levels and women with low hs-CRP levels, whereas some differences in blood pressure variables, insulin sensitivity, and inflammatory markers (IL-6 and fibrinogen) remained significant. In conclusion, these results suggest that increased visceral adipose tissue levels appear to be a determinant covariable of the association between high hs-CRP concentrations and alteration in the metabolic profile.</description><subject>Adipose Tissue</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood Pressure</subject><subject>Body Composition</subject><subject>C-Reactive Protein - analysis</subject><subject>Cardiology. Vascular system</subject><subject>Cholesterol - blood</subject><subject>Fibrinogen - analysis</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Interleukin-6 - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Postmenopause</subject><subject>Triglycerides - blood</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><subject>Viscera</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqFkV-PEjEUxSdG4-LqR9D0RZ8YbOdPhz4ZJCKbEN2sGB-bTnuBi52WbWdI-LZ-FIuQ7KNPzUl-p-fknix7y-iEUcY_7ieq22sVzKSgtJ7QYkJr9iwbsWkjciZY-TwbUUqLXLBK3GSvYtwnyVjNX2Y3rBaNqKpilP15AKt69I74DVnidpf_ABexxyP2JzLPH0DpJIDcB98DujG5cz0EC8NvdDkfk_XQ-UC-gQ4-YiSLhPuQz-xhp8ZEOUMW2AZ0fguO9J7MWuM7dMqSmcGDj0DWGOMAY_LZem9SDCQZ4OKd77yFmPK8_afXAbf2pCGgAbKCI9hI0JElKNvvTuTex74D5w9qiCnhl0_idfZio2yEN9f3Nvu5-LKeL_PV969389kq11Ut-rwsp6IUWjCgqlRct01ZNrCpS8OUMaqh2hjeKKYKLtrWgGp5VRkqikobJipR3mYfLv8egn8cUmnZYdRgrXLghyh5IzgX5TSB9QU8XywG2MhDwE6Fk2RUnqeVe3mdVp6nlbSQadrke3cNGNoOzJPrumUC3l8BFbWym6CcxvjEcVHVjJ0LfLpw6XpwRAgyagSnwWAA3Uvj8T9V_gI6lMlG</recordid><startdate>20050701</startdate><enddate>20050701</enddate><creator>Piché, Marie-Ève</creator><creator>Lemieux, Simone</creator><creator>Weisnagel, Stanley John</creator><creator>Corneau, Louise</creator><creator>Nadeau, André</creator><creator>Bergeron, Jean</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050701</creationdate><title>Relation of High-Sensitivity C-Reactive Protein, Interleukin-6, Tumor Necrosis Factor-Alpha, and Fibrinogen to Abdominal Adipose Tissue, Blood Pressure, and Cholesterol and Triglyceride Levels in Healthy Postmenopausal Women</title><author>Piché, Marie-Ève ; Lemieux, Simone ; Weisnagel, Stanley John ; Corneau, Louise ; Nadeau, André ; Bergeron, Jean</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-338939c91e0a3a6cb7337ef53d1adda70cdd67a1a269bbdeab644d0924cd19493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adipose Tissue</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Blood Pressure</topic><topic>Body Composition</topic><topic>C-Reactive Protein - analysis</topic><topic>Cardiology. Vascular system</topic><topic>Cholesterol - blood</topic><topic>Fibrinogen - analysis</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Interleukin-6 - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Postmenopause</topic><topic>Triglycerides - blood</topic><topic>Tumor Necrosis Factor-alpha - analysis</topic><topic>Viscera</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Piché, Marie-Ève</creatorcontrib><creatorcontrib>Lemieux, Simone</creatorcontrib><creatorcontrib>Weisnagel, Stanley John</creatorcontrib><creatorcontrib>Corneau, Louise</creatorcontrib><creatorcontrib>Nadeau, André</creatorcontrib><creatorcontrib>Bergeron, Jean</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Piché, Marie-Ève</au><au>Lemieux, Simone</au><au>Weisnagel, Stanley John</au><au>Corneau, Louise</au><au>Nadeau, André</au><au>Bergeron, Jean</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relation of High-Sensitivity C-Reactive Protein, Interleukin-6, Tumor Necrosis Factor-Alpha, and Fibrinogen to Abdominal Adipose Tissue, Blood Pressure, and Cholesterol and Triglyceride Levels in Healthy Postmenopausal Women</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2005-07-01</date><risdate>2005</risdate><volume>96</volume><issue>1</issue><spage>92</spage><epage>97</epage><pages>92-97</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>The associations of inflammatory markers (high-sensitivity C-reactive protein [hs-CRP], interleukin-6 [IL-6], tumor necrosis factor-α, and fibrinogen) with anthropometric and metabolic variables were examined in a sample of 112 postmenopausal women not receiving hormone therapy. Body fat distribution was measured by computed tomography, and insulin sensitivity was determined by an euglycemic-hyperinsulinemic clamp. hs-CRP (0.10 ≤ r
2 ≤0.37) and IL-6 (0.06 ≤ r
2 ≤0.31) were significantly associated with anthropometric and metabolic variables, including visceral and subcutaneous adipose tissue, systolic and diastolic blood pressure, triglycerides, high-density lipoprotein (HDL) cholesterol, and insulin sensitivity (p <0.05). Women with greater hs-CRP concentrations showed deterioration in their metabolic risk profiles, including abdominal obesity, greater triglyceride and lower HDL cholesterol concentrations, and lower insulin sensitivity compared with women with lower hs-CRP levels. Fifty-nine percent of women with high hs-CRP concentrations had the metabolic syndrome as recently defined by the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. After adjustment for visceral adipose tissue, most of the differences in the plasma lipid-lipoprotein profile were eliminated between women with high hs-CRP levels and women with low hs-CRP levels, whereas some differences in blood pressure variables, insulin sensitivity, and inflammatory markers (IL-6 and fibrinogen) remained significant. In conclusion, these results suggest that increased visceral adipose tissue levels appear to be a determinant covariable of the association between high hs-CRP concentrations and alteration in the metabolic profile.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15979442</pmid><doi>10.1016/j.amjcard.2005.02.051</doi><tpages>6</tpages></addata></record> |
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subjects | Adipose Tissue Aged Biological and medical sciences Biomarkers - blood Blood Pressure Body Composition C-Reactive Protein - analysis Cardiology. Vascular system Cholesterol - blood Fibrinogen - analysis Humans Inflammation Interleukin-6 - blood Male Medical sciences Middle Aged Postmenopause Triglycerides - blood Tumor Necrosis Factor-alpha - analysis Viscera |
title | Relation of High-Sensitivity C-Reactive Protein, Interleukin-6, Tumor Necrosis Factor-Alpha, and Fibrinogen to Abdominal Adipose Tissue, Blood Pressure, and Cholesterol and Triglyceride Levels in Healthy Postmenopausal Women |
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