Effect of Heparin on Viologen-Stimulated Enzymatic NADH Depletion

Paraquat and diquat undergo redox cycling mediated by xanthine oxidase in the NADH-dependent manner. In these processes, the rates of NADH oxidation and superoxide formation are increased almost 10-fold. The addition of heparin can substantially inhibit these processes. A protective role of heparin...

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Published in:Chemical research in toxicology 2006-05, Vol.19 (5), p.668-673
Main Authors: Zielonka, Jacek, Rybak, Małgorzata, Celińska, Joanna, Adamus, Jan, Marcinek, Andrzej, Gebicki, Jerzy
Format: Article
Language:English
Subjects:
Cytochrome c Group - chemistry
Diquat - chemistry
Heparin - chemistry
NADP - chemistry
Oxidation-Reduction
Paraquat - chemistry
Superoxides - chemistry
Xanthine Oxidase - chemistry
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cited_by cdi_FETCH-LOGICAL-a382t-4d3b1641b241727735344966b508e6df0784abaf0955973a2d0e10eb6866c69a3
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container_title Chemical research in toxicology
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creator Zielonka, Jacek
Rybak, Małgorzata
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Gebicki, Jerzy
description Paraquat and diquat undergo redox cycling mediated by xanthine oxidase in the NADH-dependent manner. In these processes, the rates of NADH oxidation and superoxide formation are increased almost 10-fold. The addition of heparin can substantially inhibit these processes. A protective role of heparin against oxygen radicals formation can be rationalized in terms of its ability to bind paraquat or diquat. The binding process has been investigated by means of the pulse radiolysis technique. Biological consequences of the binding processes are discussed.
doi_str_mv 10.1021/tx050336s
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subjects Cytochrome c Group - chemistry
Diquat - chemistry
Heparin - chemistry
NADP - chemistry
Oxidation-Reduction
Paraquat - chemistry
Superoxides - chemistry
Xanthine Oxidase - chemistry
title Effect of Heparin on Viologen-Stimulated Enzymatic NADH Depletion
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