Enzyme Mechanisms for Triterpene Cyclization: New Pieces of the Puzzle

Cationic polycyclization cascades: The stereoselective transformations of linear polyolefins to give cyclic triterpenes (see scheme) have fueled half a century of intense research. Structures of triterpene cyclases complexed with the substrate analogue 2‐azasqualene and the reaction product lanoster...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2005-06, Vol.44 (26), p.3966-3971
Main Author: Wendt, K. Ulrich
Format: Article
Language:English
Subjects:
bioorganic chemistry
Catalysis
Cyclization
enzyme catalysis
Intramolecular Transferases - chemistry
Lyases - chemistry
Models, Molecular
Molecular Structure
steroids
structural biology
terpenes
Triterpenes - chemistry
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Summary:Cationic polycyclization cascades: The stereoselective transformations of linear polyolefins to give cyclic triterpenes (see scheme) have fueled half a century of intense research. Structures of triterpene cyclases complexed with the substrate analogue 2‐azasqualene and the reaction product lanosterol provide new insights into the elegant mechanisms of these enyzmes.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200500804