Hydration properties of N-(α-hydroxyacyl)-sphingosine: X-ray powder diffraction and FT–Raman spectroscopic studies

The thermotropic properties of N-(α-hydroxyacyl)-sphingosine (CER[AS]) in dry and hydrated state were studied by means of X-ray powder diffraction and FT–Raman spectroscopy. The polymorphic states of the CER[AS]/water mixture (lamellar crystalline, lamellar hexagonal gel, liquid crystalline) depend...

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Bibliographic Details
Published in:Chemistry and physics of lipids 2005-07, Vol.136 (1), p.13-22
Main Authors: Raudenkolb, Steve, Wartewig, Siegfried, Brezesinski, Gerald, Funari, Sergio S., Neubert, Reinhard H.H.
Format: Article
Language:English
Subjects:
Ceramide
Ceramides - chemistry
Fourier Analysis
Hot Temperature
Hydration
Phase Transition
Polymorphism
Powder Diffraction
Raman spectroscopy
Spectrum Analysis, Raman - methods
Water - chemistry
X-Ray Diffraction - methods
X-ray powder diffraction
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Summary:The thermotropic properties of N-(α-hydroxyacyl)-sphingosine (CER[AS]) in dry and hydrated state were studied by means of X-ray powder diffraction and FT–Raman spectroscopy. The polymorphic states of the CER[AS]/water mixture (lamellar crystalline, lamellar hexagonal gel, liquid crystalline) depend on the thermal pre-treatment of the sample. Only by heating the CER[AS]/water mixture above the melting chain transition can the system be hydrated. At room temperature, both dry and hydrated states form lamellar structures, which differ in their repeat distance and packing of hydrocarbon chains. Above the melting chain transition, hydrated CER[AS] forms a liquid crystalline hexagonal phase, whereas anhydrous CER[AS] forms an isotropic liquid phase. The various phases of hydrated CER[AS] are distinguished on the basis of the corresponding Raman spectra.
ISSN:0009-3084
1873-2941
DOI:10.1016/j.chemphyslip.2005.03.005