A novel antioxidant agent caffeic acid phenethyl ester prevents shock wave-induced renal tubular oxidative stress

The aim of this study was to evaluate the effects of the novel free radical scavenger caffeic acid phenethyl ester (CAPE) on extracorporeal shock wave lithotripsy (ESWL) induced renal impairment. The study was performed using 30 rabbits which were divided into two groups, each exposed to 3,000 shock...

Full description

Saved in:
Bibliographic Details
Published in:Urolithiasis 2005-06, Vol.33 (3), p.239-243
Main Authors: Ozguner, Fehmi, Armagan, Abdullah, Koyu, Ahmet, Caliskan, Sadettin, Koylu, Halis
Format: Article
Language:English
Subjects:
Acetylglucosaminidase - urine
Acids
Animals
Antioxidants
Antioxidants - pharmacology
Caffeic Acids - pharmacology
Kidney Tubules - metabolism
Lithotripsy
Lithotripsy - adverse effects
Malondialdehyde - urine
Oxidative stress
Oxidative Stress - drug effects
Phenylethyl Alcohol - analogs & derivatives
Phenylethyl Alcohol - pharmacology
Rabbits
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c326t-3de9676d72e8a8c5a1c5f1af2b7d2c87226867531c7a7002f00d6fec2299c1803
cites cdi_FETCH-LOGICAL-c326t-3de9676d72e8a8c5a1c5f1af2b7d2c87226867531c7a7002f00d6fec2299c1803
container_end_page 243
container_issue 3
container_start_page 239
container_title Urolithiasis
container_volume 33
creator Ozguner, Fehmi
Armagan, Abdullah
Koyu, Ahmet
Caliskan, Sadettin
Koylu, Halis
description The aim of this study was to evaluate the effects of the novel free radical scavenger caffeic acid phenethyl ester (CAPE) on extracorporeal shock wave lithotripsy (ESWL) induced renal impairment. The study was performed using 30 rabbits which were divided into two groups, each exposed to 3,000 shock waves at 18 kV: (1) control group, (2) ESWL+CAPE treated group. Malodialdehyde (MDA), urine N-acetyl-beta-glucosaminidase (NAG) activity, uric acid and white cell counts were used as markers of oxidative stress. Following shock wave exposure there was a significant rise in MDA, NAG and uric acid and white cell counts. CAPE reduced the rise in MDA, NAG, uric acid and white cell counts. Thus CAPE treatment to a great extent prevented the induction of these renal changes. Our results suggest that the antioxidant capacity of the kidney tissue was reduced after ESWL treatment and that the tissue was exposed to oxidant stress. We conclude that CAPE treatment provided significant protection against ESWL induced free radical damage.
doi_str_mv 10.1007/s00240-005-0470-x
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67970163</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2428279731</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-3de9676d72e8a8c5a1c5f1af2b7d2c87226867531c7a7002f00d6fec2299c1803</originalsourceid><addsrcrecordid>eNpdkUtPwzAQhC0EgvL4AVyQxYGbYW0ntnNEiJeExAXOlmtvaCBNip2U8u9xaSUkLruXb0ezM4SccrjkAPoqAYgCGEDJoNDAVjtkwgtZMDC62iUTkACsVEIekMOU3gG4VpXYJwe8NFoLUUzI5zXt-iW21HVD06-akDd1b5ind3WNjafON4EuZtjhMPtuKaYBI11EXGYo0TTr_Qf9cktkTRdGj4FG7FxLh3E6ti7SX9GhWSJNQ8SUjsle7dqEJ9t9RF7vbl9uHtjT8_3jzfUT81KogcmAldIqaIHGGV867suau1pMdRDeZPfKKF1K7rXTOYcaIKgavRBV5bkBeUQuNrqL2H-O2bWdN8lj27oO-zFZpSsNXMkMnv8D3_sx5heSNabg0shKZ4hvIB_7lCLWdhGbuYvfloNdl2E3Zdhchl2XYVf55mwrPE7nGP4utunLH5p3hnE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>884138397</pqid></control><display><type>article</type><title>A novel antioxidant agent caffeic acid phenethyl ester prevents shock wave-induced renal tubular oxidative stress</title><source>Springer Link</source><creator>Ozguner, Fehmi ; Armagan, Abdullah ; Koyu, Ahmet ; Caliskan, Sadettin ; Koylu, Halis</creator><creatorcontrib>Ozguner, Fehmi ; Armagan, Abdullah ; Koyu, Ahmet ; Caliskan, Sadettin ; Koylu, Halis</creatorcontrib><description>The aim of this study was to evaluate the effects of the novel free radical scavenger caffeic acid phenethyl ester (CAPE) on extracorporeal shock wave lithotripsy (ESWL) induced renal impairment. The study was performed using 30 rabbits which were divided into two groups, each exposed to 3,000 shock waves at 18 kV: (1) control group, (2) ESWL+CAPE treated group. Malodialdehyde (MDA), urine N-acetyl-beta-glucosaminidase (NAG) activity, uric acid and white cell counts were used as markers of oxidative stress. Following shock wave exposure there was a significant rise in MDA, NAG and uric acid and white cell counts. CAPE reduced the rise in MDA, NAG, uric acid and white cell counts. Thus CAPE treatment to a great extent prevented the induction of these renal changes. Our results suggest that the antioxidant capacity of the kidney tissue was reduced after ESWL treatment and that the tissue was exposed to oxidant stress. We conclude that CAPE treatment provided significant protection against ESWL induced free radical damage.</description><identifier>ISSN: 0300-5623</identifier><identifier>ISSN: 2194-7228</identifier><identifier>EISSN: 1434-0879</identifier><identifier>EISSN: 2194-7236</identifier><identifier>DOI: 10.1007/s00240-005-0470-x</identifier><identifier>PMID: 15877224</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Acetylglucosaminidase - urine ; Acids ; Animals ; Antioxidants ; Antioxidants - pharmacology ; Caffeic Acids - pharmacology ; Kidney Tubules - metabolism ; Lithotripsy ; Lithotripsy - adverse effects ; Malondialdehyde - urine ; Oxidative stress ; Oxidative Stress - drug effects ; Phenylethyl Alcohol - analogs &amp; derivatives ; Phenylethyl Alcohol - pharmacology ; Rabbits</subject><ispartof>Urolithiasis, 2005-06, Vol.33 (3), p.239-243</ispartof><rights>Springer-Verlag 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c326t-3de9676d72e8a8c5a1c5f1af2b7d2c87226867531c7a7002f00d6fec2299c1803</citedby><cites>FETCH-LOGICAL-c326t-3de9676d72e8a8c5a1c5f1af2b7d2c87226867531c7a7002f00d6fec2299c1803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15877224$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ozguner, Fehmi</creatorcontrib><creatorcontrib>Armagan, Abdullah</creatorcontrib><creatorcontrib>Koyu, Ahmet</creatorcontrib><creatorcontrib>Caliskan, Sadettin</creatorcontrib><creatorcontrib>Koylu, Halis</creatorcontrib><title>A novel antioxidant agent caffeic acid phenethyl ester prevents shock wave-induced renal tubular oxidative stress</title><title>Urolithiasis</title><addtitle>Urol Res</addtitle><description>The aim of this study was to evaluate the effects of the novel free radical scavenger caffeic acid phenethyl ester (CAPE) on extracorporeal shock wave lithotripsy (ESWL) induced renal impairment. The study was performed using 30 rabbits which were divided into two groups, each exposed to 3,000 shock waves at 18 kV: (1) control group, (2) ESWL+CAPE treated group. Malodialdehyde (MDA), urine N-acetyl-beta-glucosaminidase (NAG) activity, uric acid and white cell counts were used as markers of oxidative stress. Following shock wave exposure there was a significant rise in MDA, NAG and uric acid and white cell counts. CAPE reduced the rise in MDA, NAG, uric acid and white cell counts. Thus CAPE treatment to a great extent prevented the induction of these renal changes. Our results suggest that the antioxidant capacity of the kidney tissue was reduced after ESWL treatment and that the tissue was exposed to oxidant stress. We conclude that CAPE treatment provided significant protection against ESWL induced free radical damage.</description><subject>Acetylglucosaminidase - urine</subject><subject>Acids</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Caffeic Acids - pharmacology</subject><subject>Kidney Tubules - metabolism</subject><subject>Lithotripsy</subject><subject>Lithotripsy - adverse effects</subject><subject>Malondialdehyde - urine</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Phenylethyl Alcohol - analogs &amp; derivatives</subject><subject>Phenylethyl Alcohol - pharmacology</subject><subject>Rabbits</subject><issn>0300-5623</issn><issn>2194-7228</issn><issn>1434-0879</issn><issn>2194-7236</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNpdkUtPwzAQhC0EgvL4AVyQxYGbYW0ntnNEiJeExAXOlmtvaCBNip2U8u9xaSUkLruXb0ezM4SccrjkAPoqAYgCGEDJoNDAVjtkwgtZMDC62iUTkACsVEIekMOU3gG4VpXYJwe8NFoLUUzI5zXt-iW21HVD06-akDd1b5ind3WNjafON4EuZtjhMPtuKaYBI11EXGYo0TTr_Qf9cktkTRdGj4FG7FxLh3E6ti7SX9GhWSJNQ8SUjsle7dqEJ9t9RF7vbl9uHtjT8_3jzfUT81KogcmAldIqaIHGGV867suau1pMdRDeZPfKKF1K7rXTOYcaIKgavRBV5bkBeUQuNrqL2H-O2bWdN8lj27oO-zFZpSsNXMkMnv8D3_sx5heSNabg0shKZ4hvIB_7lCLWdhGbuYvfloNdl2E3Zdhchl2XYVf55mwrPE7nGP4utunLH5p3hnE</recordid><startdate>20050601</startdate><enddate>20050601</enddate><creator>Ozguner, Fehmi</creator><creator>Armagan, Abdullah</creator><creator>Koyu, Ahmet</creator><creator>Caliskan, Sadettin</creator><creator>Koylu, Halis</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20050601</creationdate><title>A novel antioxidant agent caffeic acid phenethyl ester prevents shock wave-induced renal tubular oxidative stress</title><author>Ozguner, Fehmi ; Armagan, Abdullah ; Koyu, Ahmet ; Caliskan, Sadettin ; Koylu, Halis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-3de9676d72e8a8c5a1c5f1af2b7d2c87226867531c7a7002f00d6fec2299c1803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acetylglucosaminidase - urine</topic><topic>Acids</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - pharmacology</topic><topic>Caffeic Acids - pharmacology</topic><topic>Kidney Tubules - metabolism</topic><topic>Lithotripsy</topic><topic>Lithotripsy - adverse effects</topic><topic>Malondialdehyde - urine</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Phenylethyl Alcohol - analogs &amp; derivatives</topic><topic>Phenylethyl Alcohol - pharmacology</topic><topic>Rabbits</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ozguner, Fehmi</creatorcontrib><creatorcontrib>Armagan, Abdullah</creatorcontrib><creatorcontrib>Koyu, Ahmet</creatorcontrib><creatorcontrib>Caliskan, Sadettin</creatorcontrib><creatorcontrib>Koylu, Halis</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medicine (ProQuest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health &amp; Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health &amp; Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Urolithiasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ozguner, Fehmi</au><au>Armagan, Abdullah</au><au>Koyu, Ahmet</au><au>Caliskan, Sadettin</au><au>Koylu, Halis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A novel antioxidant agent caffeic acid phenethyl ester prevents shock wave-induced renal tubular oxidative stress</atitle><jtitle>Urolithiasis</jtitle><addtitle>Urol Res</addtitle><date>2005-06-01</date><risdate>2005</risdate><volume>33</volume><issue>3</issue><spage>239</spage><epage>243</epage><pages>239-243</pages><issn>0300-5623</issn><issn>2194-7228</issn><eissn>1434-0879</eissn><eissn>2194-7236</eissn><abstract>The aim of this study was to evaluate the effects of the novel free radical scavenger caffeic acid phenethyl ester (CAPE) on extracorporeal shock wave lithotripsy (ESWL) induced renal impairment. The study was performed using 30 rabbits which were divided into two groups, each exposed to 3,000 shock waves at 18 kV: (1) control group, (2) ESWL+CAPE treated group. Malodialdehyde (MDA), urine N-acetyl-beta-glucosaminidase (NAG) activity, uric acid and white cell counts were used as markers of oxidative stress. Following shock wave exposure there was a significant rise in MDA, NAG and uric acid and white cell counts. CAPE reduced the rise in MDA, NAG, uric acid and white cell counts. Thus CAPE treatment to a great extent prevented the induction of these renal changes. Our results suggest that the antioxidant capacity of the kidney tissue was reduced after ESWL treatment and that the tissue was exposed to oxidant stress. We conclude that CAPE treatment provided significant protection against ESWL induced free radical damage.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>15877224</pmid><doi>10.1007/s00240-005-0470-x</doi><tpages>5</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0300-5623
ispartof Urolithiasis, 2005-06, Vol.33 (3), p.239-243
issn 0300-5623
2194-7228
1434-0879
2194-7236
language eng
recordid cdi_proquest_miscellaneous_67970163
source Springer Link
subjects Acetylglucosaminidase - urine
Acids
Animals
Antioxidants
Antioxidants - pharmacology
Caffeic Acids - pharmacology
Kidney Tubules - metabolism
Lithotripsy
Lithotripsy - adverse effects
Malondialdehyde - urine
Oxidative stress
Oxidative Stress - drug effects
Phenylethyl Alcohol - analogs & derivatives
Phenylethyl Alcohol - pharmacology
Rabbits
title A novel antioxidant agent caffeic acid phenethyl ester prevents shock wave-induced renal tubular oxidative stress
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-23T20%3A03%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20novel%20antioxidant%20agent%20caffeic%20acid%20phenethyl%20ester%20prevents%20shock%20wave-induced%20renal%20tubular%20oxidative%20stress&rft.jtitle=Urolithiasis&rft.au=Ozguner,%20Fehmi&rft.date=2005-06-01&rft.volume=33&rft.issue=3&rft.spage=239&rft.epage=243&rft.pages=239-243&rft.issn=0300-5623&rft.eissn=1434-0879&rft_id=info:doi/10.1007/s00240-005-0470-x&rft_dat=%3Cproquest_cross%3E2428279731%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c326t-3de9676d72e8a8c5a1c5f1af2b7d2c87226867531c7a7002f00d6fec2299c1803%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=884138397&rft_id=info:pmid/15877224&rfr_iscdi=true