Hypoxia-induced tumor angiogenic pathway in head and neck cancer: an in vivo study

Numerous studies indicate the importance of hypoxia-induced pathway in tumor angiogenesis, but in vivo studies examining the importance of this mechanism in prognosis of patients with head and neck squamous cell carcinoma present conflicting results. We performed a retrospective analysis of 81 patie...

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Bibliographic Details
Published in:Cancer letters 2005-07, Vol.225 (2), p.297-304
Main Authors: Kyzas, Panayiotis A., Stefanou, Dimitrios, Batistatou, Anna, Agnantis, Niki J.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Angiogenesis
Cell Hypoxia - physiology
DNA-Binding Proteins - metabolism
Gene Expression Regulation, Neoplastic
Head & neck cancer
Head and Neck Neoplasms - blood supply
Head and Neck Neoplasms - metabolism
Head and Neck Neoplasms - pathology
HIF-1a
Humans
Hypoxia
Hypoxia-Inducible Factor 1
Hypoxia-Inducible Factor 1, alpha Subunit
Immunohistochemistry
Larynx
Medical prognosis
Middle Aged
Neovascularization, Pathologic - metabolism
Nuclear Proteins - metabolism
Prognosis
Proteins
Retrospective Studies
Rodents
Studies
Survival Analysis
Transcription Factors - metabolism
Tumors
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A - metabolism
VEGF
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Summary:Numerous studies indicate the importance of hypoxia-induced pathway in tumor angiogenesis, but in vivo studies examining the importance of this mechanism in prognosis of patients with head and neck squamous cell carcinoma present conflicting results. We performed a retrospective analysis of 81 patients with head and neck squamous cell carcinoma in order to investigate whether hypoxia-inducible factor 1a (HIF-1a) immunohistochemical expression correlates with vascular endothelial growth factor (VEGF) expression and clinicopathologic parameters or prognosis. Our results showed a statistically significant association between HIF-1a and VEGF expression in tumors located in the lower lip and in larynx, but not in those located in the oral cavity. HIF-1a expression had no impact on prognosis, while VEGF expression correlated significantly with adverse prognosis. These findings support the hypothesis that tumor angiogenesis is close related, but not strictly dependent, on the hypoxic conditions of tumor's microenvironment.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2004.11.060