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Progressive sleep ‘destructuring’ in Parkinson's disease. A polysomnographic study in 46 patients
Sleep abnormalities in Parkinson's disease (PD) are frequent, but it is unknown whether or not there is progressive loss of physiological sleep architecture or what the causes could be. Retrospective review of medical records and polysomnographic data from 46 non-demented PD patients. Sleep lat...
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| Published in: | Sleep medicine 2005-07, Vol.6 (4), p.313-318 |
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| Language: | English |
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| container_end_page | 318 |
| container_issue | 4 |
| container_start_page | 313 |
| container_title | Sleep medicine |
| container_volume | 6 |
| creator | Diederich, Nico J. Vaillant, Michel Mancuso, Giovanna Lyen, Peter Tiete, Jo |
| description | Sleep abnormalities in Parkinson's disease (PD) are frequent, but it is unknown whether or not there is
progressive loss of physiological sleep architecture or what the causes could be.
Retrospective review of medical records and polysomnographic data from 46 non-demented PD patients.
Sleep latency was correlated with disease duration (F1,44=4.87,
P=0.03). Total sleep time (F1,44=8.54,
P=0.005), deep sleep time (F1,44=4.06,
P=0.05), REM sleep time (F1,44=9.15,
P=0.004) and sleep efficiency (SE) (F1,44=10.20,
P=0.003) were inversely correlated with disease duration. The same sleep parameters were independent from the degree of motor impairment, dosage of the dopaminergic medications, and age. Subjective sleep complaints could only partially predict abnormalities in polysomnographic (PSG) studies.
In PD nocturnal sleep ‘destructuring’ is linked to disease duration and evolves independently from other major disease parameters. |
| doi_str_mv | 10.1016/j.sleep.2005.03.011 |
| format | article |
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progressive loss of physiological sleep architecture or what the causes could be.
Retrospective review of medical records and polysomnographic data from 46 non-demented PD patients.
Sleep latency was correlated with disease duration (F1,44=4.87,
P=0.03). Total sleep time (F1,44=8.54,
P=0.005), deep sleep time (F1,44=4.06,
P=0.05), REM sleep time (F1,44=9.15,
P=0.004) and sleep efficiency (SE) (F1,44=10.20,
P=0.003) were inversely correlated with disease duration. The same sleep parameters were independent from the degree of motor impairment, dosage of the dopaminergic medications, and age. Subjective sleep complaints could only partially predict abnormalities in polysomnographic (PSG) studies.
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progressive loss of physiological sleep architecture or what the causes could be.
Retrospective review of medical records and polysomnographic data from 46 non-demented PD patients.
Sleep latency was correlated with disease duration (F1,44=4.87,
P=0.03). Total sleep time (F1,44=8.54,
P=0.005), deep sleep time (F1,44=4.06,
P=0.05), REM sleep time (F1,44=9.15,
P=0.004) and sleep efficiency (SE) (F1,44=10.20,
P=0.003) were inversely correlated with disease duration. The same sleep parameters were independent from the degree of motor impairment, dosage of the dopaminergic medications, and age. Subjective sleep complaints could only partially predict abnormalities in polysomnographic (PSG) studies.
In PD nocturnal sleep ‘destructuring’ is linked to disease duration and evolves independently from other major disease parameters.</description><subject>Adult</subject><subject>Aged</subject><subject>Disorders of Excessive Somnolence - diagnosis</subject><subject>Disorders of Excessive Somnolence - epidemiology</subject><subject>Excessive daytime sleepiness</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Parkinson Disease - epidemiology</subject><subject>Parkinson's disease</subject><subject>Polysomnography</subject><subject>REM sleep behavior disorder</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><subject>Sleep architecture</subject><subject>Sleep Wake Disorders - diagnosis</subject><subject>Sleep Wake Disorders - epidemiology</subject><subject>Sleep, REM - physiology</subject><issn>1389-9457</issn><issn>1878-5506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNp9kLFu2zAQhokiQZw6eYICBad0ksoTJZEaMgRGmgYI0AzZCZo8uXRlSeVJAbz5MdLXy5NUjg1kyy13w___h_9j7AuIFASU39cpNYh9mglRpEKmAuATOwetdFIUojyZbqmrpMoLNWOfidZCgAKdn7EZFFVe6kqdM3yM3SoiUXhG_pbHX3cvHmmIoxvGGNrV6-4fDy1_tPFPaKlrvxH3gdASpvyG912zpW7TTim2_x0cp2H0270hL3lvh4DtQBfstLYN4eVxz9nTj9unxc_k4dfd_eLmIXGyUEOiMynrwgqfqbIuJXrrdK1qENKCUtY5m5UADqzVWOmldM7nculA1kpAlck5uzrE9rH7O04dzCaQw6axLXYjmVJVSu5nzuRB6GJHFLE2fQwbG7cGhNnDNWvzBsPs4RohzQR3cn09xo_LDfp3z5HmJLg-CHDq-BwwGnJTf4c-RHSD8V348MF_njSPqA</recordid><startdate>20050701</startdate><enddate>20050701</enddate><creator>Diederich, Nico J.</creator><creator>Vaillant, Michel</creator><creator>Mancuso, Giovanna</creator><creator>Lyen, Peter</creator><creator>Tiete, Jo</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050701</creationdate><title>Progressive sleep ‘destructuring’ in Parkinson's disease. A polysomnographic study in 46 patients</title><author>Diederich, Nico J. ; Vaillant, Michel ; Mancuso, Giovanna ; Lyen, Peter ; Tiete, Jo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-8233f5a0d276f63edac8f7f103a177acca2611c1aa8e98b3ccd43bc13f701923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Disorders of Excessive Somnolence - diagnosis</topic><topic>Disorders of Excessive Somnolence - epidemiology</topic><topic>Excessive daytime sleepiness</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Parkinson Disease - epidemiology</topic><topic>Parkinson's disease</topic><topic>Polysomnography</topic><topic>REM sleep behavior disorder</topic><topic>Retrospective Studies</topic><topic>Severity of Illness Index</topic><topic>Sleep architecture</topic><topic>Sleep Wake Disorders - diagnosis</topic><topic>Sleep Wake Disorders - epidemiology</topic><topic>Sleep, REM - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Diederich, Nico J.</creatorcontrib><creatorcontrib>Vaillant, Michel</creatorcontrib><creatorcontrib>Mancuso, Giovanna</creatorcontrib><creatorcontrib>Lyen, Peter</creatorcontrib><creatorcontrib>Tiete, Jo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Sleep medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diederich, Nico J.</au><au>Vaillant, Michel</au><au>Mancuso, Giovanna</au><au>Lyen, Peter</au><au>Tiete, Jo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Progressive sleep ‘destructuring’ in Parkinson's disease. A polysomnographic study in 46 patients</atitle><jtitle>Sleep medicine</jtitle><addtitle>Sleep Med</addtitle><date>2005-07-01</date><risdate>2005</risdate><volume>6</volume><issue>4</issue><spage>313</spage><epage>318</epage><pages>313-318</pages><issn>1389-9457</issn><eissn>1878-5506</eissn><abstract>Sleep abnormalities in Parkinson's disease (PD) are frequent, but it is unknown whether or not there is
progressive loss of physiological sleep architecture or what the causes could be.
Retrospective review of medical records and polysomnographic data from 46 non-demented PD patients.
Sleep latency was correlated with disease duration (F1,44=4.87,
P=0.03). Total sleep time (F1,44=8.54,
P=0.005), deep sleep time (F1,44=4.06,
P=0.05), REM sleep time (F1,44=9.15,
P=0.004) and sleep efficiency (SE) (F1,44=10.20,
P=0.003) were inversely correlated with disease duration. The same sleep parameters were independent from the degree of motor impairment, dosage of the dopaminergic medications, and age. Subjective sleep complaints could only partially predict abnormalities in polysomnographic (PSG) studies.
In PD nocturnal sleep ‘destructuring’ is linked to disease duration and evolves independently from other major disease parameters.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>15946897</pmid><doi>10.1016/j.sleep.2005.03.011</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1389-9457 |
| ispartof | Sleep medicine, 2005-07, Vol.6 (4), p.313-318 |
| issn | 1389-9457 1878-5506 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67973333 |
| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Adult Aged Disorders of Excessive Somnolence - diagnosis Disorders of Excessive Somnolence - epidemiology Excessive daytime sleepiness Female Humans Male Middle Aged Parkinson Disease - epidemiology Parkinson's disease Polysomnography REM sleep behavior disorder Retrospective Studies Severity of Illness Index Sleep architecture Sleep Wake Disorders - diagnosis Sleep Wake Disorders - epidemiology Sleep, REM - physiology |
| title | Progressive sleep ‘destructuring’ in Parkinson's disease. A polysomnographic study in 46 patients |
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