Learning in realistic networks of spiking neurons and spike-driven plastic synapses

• Published in: The European journal of neuroscience 2005-06, Vol.21 (11), p.3143-3160
• Main Authors: Mongillo, Gianluigi, Curti, Emanuele, Romani, Sandro, Amit, Daniel J.
• Format: Article
• Language: English
• Subjects: Action Potentials - physiology; Animals; Central Nervous System - physiology; delayed response task; Electric Stimulation; Humans; long-term plasticity; Memory, Short-Term - physiology; Nerve Net - physiology; Neural Inhibition - physiology; Neural Networks (Computer); Neural Pathways - physiology; Neuronal Plasticity - physiology; Neurons - physiology; persistent activity; Receptors, N-Methyl-D-Aspartate - physiology; short-term synaptic depression; Synapses - physiology; Synaptic Transmission - physiology; working memory
• ISSN: 0953-816X; 1460-9568
• DOI: 10.1111/j.1460-9568.2005.04087.x

We have used simulations to study the learning dynamics of an autonomous, biologically realistic recurrent network of spiking neurons connected via plastic synapses, subjected to a stream of stimulus–delay trials, in which one of a set of stimuli is presented followed by a delay. Long‐term plasticity, produced by the neural activity experienced during training, structures the network and endows it with active (working) memory, i.e. enhanced, selective delay activity for every stimulus in the training set. Short‐term plasticity produces transient synaptic depression. Each stimulus used in training excites a selective subset of neurons in the network, and stimuli can share neurons (overlapping stimuli). Long‐term plasticity dynamics are driven by presynaptic spikes and coincident postsynaptic depolarization; stability is ensured by a refresh mechanism. In the absence of stimulation, the acquired synaptic structure persists for a very long time. The dependence of long‐term plasticity dynamics on the characteristics of the stimulus response (average emission rates, time course and synchronization), and on the single‐cell emission statistics (coefficient of variation) is studied. The study clarifies the specific roles of short‐term synaptic depression, NMDA receptors, stimulus representation overlaps, selective stimulation of inhibition, and spike asynchrony during stimulation. Patterns of network spiking activity before, during and after training reproduce most of the in vivo physiological observations in the literature.