Weekly electrocardiographic pattern in mice infected with two different Trypanosoma cruzi strains

Chagas' disease, which is caused by Trypanosoma cruzi, affects 20 million people. The electrocardiographic alterations are usually the first evidence of disease progression. In this work, we evaluated if two different T. cruzi strains presented electrocardiographic and heart histopathological a...

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Bibliographic Details
Published in:International journal of cardiology 2005-07, Vol.102 (2), p.211-217
Main Authors: Bustamante, Juan M., Rivarola, H.W., Fretes, Ricardo, Paglini-Oliva, Patricia A.
Format: Article
Language:English
Subjects:
Animals
Arrhythmias, Cardiac - etiology
Arrhythmias, Cardiac - physiopathology
Biological and medical sciences
Cardiology. Vascular system
Chagas Cardiomyopathy - complications
Chagas Cardiomyopathy - pathology
Chagas Cardiomyopathy - physiopathology
Disease Models, Animal
Electrocardiography
Female
Follow-Up Studies
Heart - parasitology
Medical sciences
Mice
Myocardium - pathology
T. cruzi strains
Time Factors
Trypanosoma cruzi
Trypanosoma cruzi - isolation & purification
Trypanosoma cruzi - pathogenicity
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Summary:Chagas' disease, which is caused by Trypanosoma cruzi, affects 20 million people. The electrocardiographic alterations are usually the first evidence of disease progression. In this work, we evaluated if two different T. cruzi strains presented electrocardiographic and heart histopathological alterations that could be characteristic and only achieved to the parasite strain. The moment when the electric alterations began was also studied. Albino mice ( n=100) were inoculated with 50 ( n=50) and 500 ( n=50) trypomastigotes of T. cruzi, for Tulahuen strain and SGO-Z12 isolate, respectively. Electrocardiograms were obtained before infection and once a week from 7 to 147 days post infection (d.p.i). Dipolar and unipolar leads were analyzed. Hearts were removed by necropsy on 14, 90 and 147 d.p.i. Each heart was cut horizontally into 5-μm sections and they were stained with Hematoxilin–Eosine. At 147 d.p.i., 30% of Tul-infected mice were found alive, while in the SGO-Z12 infected group, 75% were alive at the same moment. The Tul-infected group showed more intraventricular blockage alterations than the other groups from 49 to 70 d.p.i, ( p
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2004.05.014