A Complete Mock Circulation Loop for the Evaluation of Left, Right, and Biventricular Assist Devices

:  A new mock circulation loop was developed to replicate the necessary features of the systemic and pulmonic circulatory systems, including pulsatile left and right ventricles coupled with vascular compliances and resistances. A brief description of the mock loop construction is provided before res...

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Bibliographic Details
Published in:Artificial organs 2005-07, Vol.29 (7), p.564-572
Main Authors: Timms, Daniel, Hayne, Mark, McNeil, Keith, Galbraith, Andrew
Format: Article
Language:English
Subjects:
Blood Circulation - physiology
Blood Pressure - physiology
Cardiovascular System - physiopathology
Equipment Design
Equipment Failure Analysis
Extracorporeal Circulation - instrumentation
Heart Failure - physiopathology
Heart-Assist Devices
Hemodynamics
Hemorheology
Humans
Models, Cardiovascular
Pulsatile mock circulation loop
Vascular Resistance - physiology
Ventricular assist device
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Summary::  A new mock circulation loop was developed to replicate the necessary features of the systemic and pulmonic circulatory systems, including pulsatile left and right ventricles coupled with vascular compliances and resistances. A brief description of the mock loop construction is provided before results are presented confirming the recreation of perfusion rates and pressures found in the natural systemic and pulmonic vascular trees for a normal and failing heart at rest. This rig provides the ability to evaluate the hemodynamic effect of left, right, and  biventricular assist devices in vitro. The small and compact mock circulation rig has the potential to reduce device evaluation costs by simulating the natural circulatory system, thus providing valuable device performance feedback prior to expensive in vivo animal trials.
ISSN:0160-564X
1525-1594
DOI:10.1111/j.1525-1594.2005.29094.x