Polymorphism in the CD5 gene promoter in B-cell chronic lymphocytic leukemia and mantle cell lymphoma

Despite the low incidence of microsatellite instability (MSI) in lymphoid malignant neoplasms, it has been reported that the CD5 promoter MSI was relatively frequent among B-cell chronic lymphoproliferative disorders. We studied the presence of MSI in the CD5 promoter in 134 cases of B-cell chronic...

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Bibliographic Details
Published in:American journal of clinical pathology 2005-05, Vol.123 (5), p.646-650
Main Authors: PEREZ-CHACON, Gema, CONTRERAS-MARTIN, Beatriz, PEREZ-ACIEGO, Paloma, CUNI, Sandra, ROSADO, Silvia, MARTIN-DONAIRE, Trinidad, LOSADA-FERNANDEZ, Ignacio, VARGAS, Juan A, JORDA, Julia, ALVAREZ, Natalia, GARCIA-MARCO, José
Format: Article
Language:English
Subjects:
Biological and medical sciences
CD5 Antigens - genetics
DNA, Neoplasm - analysis
Gene Frequency
Genetic Predisposition to Disease
Hematologic and hematopoietic diseases
Humans
Investigative techniques, diagnostic techniques (general aspects)
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
Leukemia, Lymphocytic, Chronic, B-Cell - pathology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma, Mantle-Cell - genetics
Lymphoma, Mantle-Cell - pathology
Medical sciences
Microsatellite Repeats - genetics
Odds Ratio
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Polymorphism, Genetic
Promoter Regions, Genetic
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Summary:Despite the low incidence of microsatellite instability (MSI) in lymphoid malignant neoplasms, it has been reported that the CD5 promoter MSI was relatively frequent among B-cell chronic lymphoproliferative disorders. We studied the presence of MSI in the CD5 promoter in 134 cases of B-cell chronic lymphocytic leukemia (B-CLL) and 47 of mantle cell lymphoma (MCL) by comparing the pattern of microsatellite repeats on autologous germline and tumor DNA samples. Microsatellite alterations were not observed in any case. However, the allele distribution of this polymorphism showed a higher frequency of the 18 CA allele (0.585) in MCL cases (P = .026; odds ratio [OR], 1.75; 95% confidence interval [CI], 1.07-2.87) and of the 19 CA allele (0.179) in B-CLL cases (P = .005; OR, 2.26; 95% CI, 1.27-4.01) compared with control cases (0.442 and 0.087, respectively). This suggests that although MSI seems not to be involved in the pathogenesis of these 2 lymphoid malignant neoplasms, the polymorphic CD5 promoter is associated with increased susceptibility to these disorders.
ISSN:0002-9173
1943-7722
DOI:10.1309/F0YH31T4438WNJQM