Molecular Aspects of Ischemic Heart Disease: Ischemia/Reperfusion–Induced Genetic Changes and Potential Applications of Gene and RNA Interference Therapy

Molecular biologic techniques have a variety of applications in the study of ischemic heart disease, including roles in elucidating cardiac genetic changes resulting from ischemia as well as in developing therapeutic interventions to treat ischemic heart disease. This review describes recent studies...

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Bibliographic Details
Published in:Journal of cardiovascular pharmacology and therapeutics 2006-03, Vol.11 (1), p.17-30
Main Authors: Nordlie, Margaret A., Wold, Loren E., Simkhovich, Boris Z., Sesti, Casilde, Kloner, Robert A.
Format: Article
Language:English
Subjects:
Animals
Clinical Trials as Topic
Combined Modality Therapy
Fibroblast Growth Factors - genetics
Fibroblast Growth Factors - therapeutic use
Gene Expression Profiling
Genetic Therapy
Heart Failure - genetics
Heart Failure - therapy
Humans
Infusions, Intra-Arterial
Myocardial Infarction - drug therapy
Myocardial Infarction - genetics
Myocardial Infarction - metabolism
Myocardial Ischemia - genetics
Myocardial Ischemia - therapy
Myocardial Reperfusion Injury - genetics
Myocardial Reperfusion Injury - metabolism
Myocardium - metabolism
Neovascularization, Physiologic - genetics
RNA Interference
Stem Cell Transplantation
Vascular Endothelial Growth Factors - genetics
Vascular Endothelial Growth Factors - therapeutic use
Ventricular Remodeling - genetics
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Summary:Molecular biologic techniques have a variety of applications in the study of ischemic heart disease, including roles in elucidating cardiac genetic changes resulting from ischemia as well as in developing therapeutic interventions to treat ischemic heart disease. This review describes recent studies documenting genetic changes associated with myocardial ischemia and infarction as well as those investigating the safety and effectiveness of gene therapy for stimulating angiogenesis, protecting the heart against reperfusion injury, and treating heart failure. Also discussed are future research directions, including the potential use of RNA interference and combined stem cell therapy and gene therapy for the treatment of cardiovascular disease.
ISSN:1074-2484
1940-4034
DOI:10.1177/107424840601100102