Yellow fever vaccine-associated viscerotropic disease and death in Spain

• Published in: Journal of clinical virology 2006-06, Vol.36 (2), p.156-158
• Main Authors: Doblas, A., Domingo, C., Bae, H.G., Bohórquez, C.L., de Ory, F, Niedrig, M., Mora, D., Carrasco, F.J., Tenorio, A.
• Format: Article
• Language: English
• Subjects: Adult; Arboviroses; Biological and medical sciences; Fatal Outcome; Female; Fundamental and applied biological sciences. Psychology; Human viral diseases; Humans; Infectious diseases; Medical sciences; Microbiology; Miscellaneous; Spain; Tropical viral diseases; Vaccination; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies; Viral diseases; Virology; Viscerotropic adverse event; Yellow fever; Yellow Fever - etiology; Yellow Fever - prevention & control; Yellow fever vaccine; Yellow Fever Vaccine - administration & dosage; Yellow Fever Vaccine - adverse effects
• ISSN: 1386-6532; 1873-5967
• DOI: 10.1016/j.jcv.2006.02.005

Yellow fever vaccine-associated viscerotropic disease (YEL-AVD) is a recently described severe adverse event after yellow fever vaccination, and some cases have been reported in different countries [Anonymous. Effects of yellow fever and vaccination. Lancet 2001;358(9296):1907–9]. Herein we describe a YEL-AVD case in a young woman, who died after vaccination with 17D-204 strain. Clinical, serological and immunochemical analysis as well as virus detection, quantification, sequence analysis and cytokine release, were performed. Further investigations on yellow fever vaccine adverse events, and carefully analysis of the immune response elicited are important tasks for the future.