The Role of Adiponectin in Atherosclerosis and Thrombosis

Obesity is a major risk factor for morbidity and mortality from cardiovascular causes. Adiponectin has been identified recently as one of the adipocytokines with important metabolic effects. It can suppress atherogenesis by inhibiting the adherence of monocytes, reducing their phagocytic activity, a...

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Bibliographic Details
Published in:Clinical and applied thrombosis/hemostasis 2006-04, Vol.12 (2), p.163-168
Main Authors: Ekmekci, Hakan, Ekmekci, Ozlem B.
Format: Article
Language:English
Subjects:
Adiponectin - physiology
Atherosclerosis
Atherosclerosis - etiology
Atherosclerosis - metabolism
Atherosclerosis - pathology
Endothelium, Vascular - pathology
Humans
Lipoproteins - metabolism
Monocytes - physiology
Thrombosis - etiology
Thrombosis - metabolism
Thrombosis - pathology
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Summary:Obesity is a major risk factor for morbidity and mortality from cardiovascular causes. Adiponectin has been identified recently as one of the adipocytokines with important metabolic effects. It can suppress atherogenesis by inhibiting the adherence of monocytes, reducing their phagocytic activity, and suppressing the accumulation of modified lipoproteins in the vascular wall. In addition, as adiponectin decrease endothelial damage and stimulates production of NO from vascular endothelial cells, hypoadiponectinemia may be partially contribute to thrombus formation.
ISSN:1076-0296
1938-2723
DOI:10.1177/107602960601200203