Loading…
Alternative 3′ UTR polyadenylation of Bzw1 transcripts display differential translation efficiency and tissue-specific expression
BZW1 is a conserved regulatory factor for transcriptional control of histone H4 gene at the G1/S transition. In this study, three Bzw1 transcripts were identified in mice with two long forms (∼2.9 kb) expressed ubiquitously at low level, and a short transcript of 1.8 kb expressed at high level exclu...
Saved in:
| Published in: | Biochemical and biophysical research communications 2006-06, Vol.345 (1), p.479-485 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c451t-9274b7af02860ed625618e167196950c35984142007d4eb0ebcd3d9770ce7c1b3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c451t-9274b7af02860ed625618e167196950c35984142007d4eb0ebcd3d9770ce7c1b3 |
| container_end_page | 485 |
| container_issue | 1 |
| container_start_page | 479 |
| container_title | Biochemical and biophysical research communications |
| container_volume | 345 |
| creator | Yu, Mingyan Sha, Haibo Gao, Yan Zeng, Hu Zhu, Minsheng Gao, Xiang |
| description | BZW1 is a conserved regulatory factor for transcriptional control of histone H4 gene at the G1/S transition. In this study, three
Bzw1 transcripts were identified in mice with two long forms (∼2.9
kb) expressed ubiquitously at low level, and a short transcript of 1.8
kb expressed at high level exclusively in testis. These different transcripts share the same 5′ UTR and coding sequence, but differ in the length of 3′ UTR by utilizing alternative polyadenylation sites. Different translation efficiencies were observed in the cells transfected with chimeric EGFP-Bzw1 genes tailed with different 3′ UTRs. Our results demonstrate that
Bzw1 transcripts are alternatively polyadenylated and expressed in tissue-specific pattern. |
| doi_str_mv | 10.1016/j.bbrc.2006.04.113 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67979114</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006291X06009491</els_id><sourcerecordid>17220943</sourcerecordid><originalsourceid>FETCH-LOGICAL-c451t-9274b7af02860ed625618e167196950c35984142007d4eb0ebcd3d9770ce7c1b3</originalsourceid><addsrcrecordid>eNqFkcGKFDEYhIMo7rj6Ah4kJ2_d_n86k0zAy7roKiwIsgveQjr5GzL0dLdJz2p7EnwjH2mfxIwz4E1Pdaiv6lDF2HOEGgHVq23dtsnXAkDVIGvE5gFbIRioBIJ8yFZQnEoY_HzGnuS8BUCUyjxmZ6iUAWhwxX5e9DOlwc3xjnhz_-MXv735xKexX1ygYemLMQ587Pib71-Rz8kN2ac4zZmHmKfeLUW7jhINc3T9ETiFqOuijzT4hbsh8DnmvKcqT-RjMTh9mxLlXMin7FHn-kzPTnrObt-9vbl8X11_vPpweXFdebnGuTJCy1a7DsRGAQUl1go3hEqjUWYNvlmbjURZ5tBBUgvU-tAEozV40h7b5py9PPZOafyypzzbXcye-t4NNO6zVdpoUyb6L4haCDCyKaA4gj6NOSfq7JTizqXFItjDR3ZrDx_Zw0cWpC0fldCLU_u-3VH4GzmdUoDXR4DKGHeRks1_dqQQE_nZhjH-q_83FIOllg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17220943</pqid></control><display><type>article</type><title>Alternative 3′ UTR polyadenylation of Bzw1 transcripts display differential translation efficiency and tissue-specific expression</title><source>ScienceDirect Freedom Collection</source><creator>Yu, Mingyan ; Sha, Haibo ; Gao, Yan ; Zeng, Hu ; Zhu, Minsheng ; Gao, Xiang</creator><creatorcontrib>Yu, Mingyan ; Sha, Haibo ; Gao, Yan ; Zeng, Hu ; Zhu, Minsheng ; Gao, Xiang</creatorcontrib><description>BZW1 is a conserved regulatory factor for transcriptional control of histone H4 gene at the G1/S transition. In this study, three
Bzw1 transcripts were identified in mice with two long forms (∼2.9
kb) expressed ubiquitously at low level, and a short transcript of 1.8
kb expressed at high level exclusively in testis. These different transcripts share the same 5′ UTR and coding sequence, but differ in the length of 3′ UTR by utilizing alternative polyadenylation sites. Different translation efficiencies were observed in the cells transfected with chimeric EGFP-Bzw1 genes tailed with different 3′ UTRs. Our results demonstrate that
Bzw1 transcripts are alternatively polyadenylated and expressed in tissue-specific pattern.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2006.04.113</identifier><identifier>PMID: 16690031</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>3' Untranslated Regions - genetics ; 3′ UTR ; Alternative polyadenylation site ; Alternative Splicing ; Animals ; Bzw1 ; Cell Cycle Proteins - genetics ; Cell Cycle Proteins - metabolism ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Male ; Mice ; Organ Specificity ; Polyadenylation - genetics ; Protein Biosynthesis - genetics ; Spermatogonia - metabolism ; Testis ; Tissue Distribution ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Translational efficiency</subject><ispartof>Biochemical and biophysical research communications, 2006-06, Vol.345 (1), p.479-485</ispartof><rights>2006 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-9274b7af02860ed625618e167196950c35984142007d4eb0ebcd3d9770ce7c1b3</citedby><cites>FETCH-LOGICAL-c451t-9274b7af02860ed625618e167196950c35984142007d4eb0ebcd3d9770ce7c1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16690031$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Mingyan</creatorcontrib><creatorcontrib>Sha, Haibo</creatorcontrib><creatorcontrib>Gao, Yan</creatorcontrib><creatorcontrib>Zeng, Hu</creatorcontrib><creatorcontrib>Zhu, Minsheng</creatorcontrib><creatorcontrib>Gao, Xiang</creatorcontrib><title>Alternative 3′ UTR polyadenylation of Bzw1 transcripts display differential translation efficiency and tissue-specific expression</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>BZW1 is a conserved regulatory factor for transcriptional control of histone H4 gene at the G1/S transition. In this study, three
Bzw1 transcripts were identified in mice with two long forms (∼2.9
kb) expressed ubiquitously at low level, and a short transcript of 1.8
kb expressed at high level exclusively in testis. These different transcripts share the same 5′ UTR and coding sequence, but differ in the length of 3′ UTR by utilizing alternative polyadenylation sites. Different translation efficiencies were observed in the cells transfected with chimeric EGFP-Bzw1 genes tailed with different 3′ UTRs. Our results demonstrate that
Bzw1 transcripts are alternatively polyadenylated and expressed in tissue-specific pattern.</description><subject>3' Untranslated Regions - genetics</subject><subject>3′ UTR</subject><subject>Alternative polyadenylation site</subject><subject>Alternative Splicing</subject><subject>Animals</subject><subject>Bzw1</subject><subject>Cell Cycle Proteins - genetics</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Male</subject><subject>Mice</subject><subject>Organ Specificity</subject><subject>Polyadenylation - genetics</subject><subject>Protein Biosynthesis - genetics</subject><subject>Spermatogonia - metabolism</subject><subject>Testis</subject><subject>Tissue Distribution</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Translational efficiency</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqFkcGKFDEYhIMo7rj6Ah4kJ2_d_n86k0zAy7roKiwIsgveQjr5GzL0dLdJz2p7EnwjH2mfxIwz4E1Pdaiv6lDF2HOEGgHVq23dtsnXAkDVIGvE5gFbIRioBIJ8yFZQnEoY_HzGnuS8BUCUyjxmZ6iUAWhwxX5e9DOlwc3xjnhz_-MXv735xKexX1ygYemLMQ587Pib71-Rz8kN2ac4zZmHmKfeLUW7jhINc3T9ETiFqOuijzT4hbsh8DnmvKcqT-RjMTh9mxLlXMin7FHn-kzPTnrObt-9vbl8X11_vPpweXFdebnGuTJCy1a7DsRGAQUl1go3hEqjUWYNvlmbjURZ5tBBUgvU-tAEozV40h7b5py9PPZOafyypzzbXcye-t4NNO6zVdpoUyb6L4haCDCyKaA4gj6NOSfq7JTizqXFItjDR3ZrDx_Zw0cWpC0fldCLU_u-3VH4GzmdUoDXR4DKGHeRks1_dqQQE_nZhjH-q_83FIOllg</recordid><startdate>20060623</startdate><enddate>20060623</enddate><creator>Yu, Mingyan</creator><creator>Sha, Haibo</creator><creator>Gao, Yan</creator><creator>Zeng, Hu</creator><creator>Zhu, Minsheng</creator><creator>Gao, Xiang</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>20060623</creationdate><title>Alternative 3′ UTR polyadenylation of Bzw1 transcripts display differential translation efficiency and tissue-specific expression</title><author>Yu, Mingyan ; Sha, Haibo ; Gao, Yan ; Zeng, Hu ; Zhu, Minsheng ; Gao, Xiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-9274b7af02860ed625618e167196950c35984142007d4eb0ebcd3d9770ce7c1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>3' Untranslated Regions - genetics</topic><topic>3′ UTR</topic><topic>Alternative polyadenylation site</topic><topic>Alternative Splicing</topic><topic>Animals</topic><topic>Bzw1</topic><topic>Cell Cycle Proteins - genetics</topic><topic>Cell Cycle Proteins - metabolism</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Male</topic><topic>Mice</topic><topic>Organ Specificity</topic><topic>Polyadenylation - genetics</topic><topic>Protein Biosynthesis - genetics</topic><topic>Spermatogonia - metabolism</topic><topic>Testis</topic><topic>Tissue Distribution</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>Translational efficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Mingyan</creatorcontrib><creatorcontrib>Sha, Haibo</creatorcontrib><creatorcontrib>Gao, Yan</creatorcontrib><creatorcontrib>Zeng, Hu</creatorcontrib><creatorcontrib>Zhu, Minsheng</creatorcontrib><creatorcontrib>Gao, Xiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Mingyan</au><au>Sha, Haibo</au><au>Gao, Yan</au><au>Zeng, Hu</au><au>Zhu, Minsheng</au><au>Gao, Xiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alternative 3′ UTR polyadenylation of Bzw1 transcripts display differential translation efficiency and tissue-specific expression</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2006-06-23</date><risdate>2006</risdate><volume>345</volume><issue>1</issue><spage>479</spage><epage>485</epage><pages>479-485</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>BZW1 is a conserved regulatory factor for transcriptional control of histone H4 gene at the G1/S transition. In this study, three
Bzw1 transcripts were identified in mice with two long forms (∼2.9
kb) expressed ubiquitously at low level, and a short transcript of 1.8
kb expressed at high level exclusively in testis. These different transcripts share the same 5′ UTR and coding sequence, but differ in the length of 3′ UTR by utilizing alternative polyadenylation sites. Different translation efficiencies were observed in the cells transfected with chimeric EGFP-Bzw1 genes tailed with different 3′ UTRs. Our results demonstrate that
Bzw1 transcripts are alternatively polyadenylated and expressed in tissue-specific pattern.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16690031</pmid><doi>10.1016/j.bbrc.2006.04.113</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-291X |
| ispartof | Biochemical and biophysical research communications, 2006-06, Vol.345 (1), p.479-485 |
| issn | 0006-291X 1090-2104 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67979114 |
| source | ScienceDirect Freedom Collection |
| subjects | 3' Untranslated Regions - genetics 3′ UTR Alternative polyadenylation site Alternative Splicing Animals Bzw1 Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Male Mice Organ Specificity Polyadenylation - genetics Protein Biosynthesis - genetics Spermatogonia - metabolism Testis Tissue Distribution Transcription Factors - genetics Transcription Factors - metabolism Translational efficiency |
| title | Alternative 3′ UTR polyadenylation of Bzw1 transcripts display differential translation efficiency and tissue-specific expression |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T22%3A09%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Alternative%203%E2%80%B2%20UTR%20polyadenylation%20of%20Bzw1%20transcripts%20display%20differential%20translation%20efficiency%20and%20tissue-specific%20expression&rft.jtitle=Biochemical%20and%20biophysical%20research%20communications&rft.au=Yu,%20Mingyan&rft.date=2006-06-23&rft.volume=345&rft.issue=1&rft.spage=479&rft.epage=485&rft.pages=479-485&rft.issn=0006-291X&rft.eissn=1090-2104&rft_id=info:doi/10.1016/j.bbrc.2006.04.113&rft_dat=%3Cproquest_cross%3E17220943%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c451t-9274b7af02860ed625618e167196950c35984142007d4eb0ebcd3d9770ce7c1b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=17220943&rft_id=info:pmid/16690031&rfr_iscdi=true |