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Virulence factors in enterococcal infections of orthopedic devices
Enterococci are opportunistic pathogens which today represent one of the leading causes of nosocomial infections. We have examined a collection of 52 Enterococcus faecalis isolated from orthopedic infections to determine if they were characterized by a specific pattern of virulence factors. The isol...
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Published in: | International journal of artificial organs 2006-04, Vol.29 (4), p.402-406 |
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container_title | International journal of artificial organs |
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creator | Baldassarri, L Creti, R Recchia, S Pataracchia, M Alfarone, G Orefici, G Campoccia, D Montanaro, L Arciola, C R |
description | Enterococci are opportunistic pathogens which today represent one of the leading causes of nosocomial infections. We have examined a collection of 52 Enterococcus faecalis isolated from orthopedic infections to determine if they were characterized by a specific pattern of virulence factors. The isolates were evaluated for biofilm formation, presence of genes coding the enterococcal surface protein (esp) and gelatinase (gelE), as well as for gelatinase production. While the rate of esp-positive isolates was comparable to that found among strains from other clinical sources, we found a significantly higher rate of strong biofilm formers and gelatinase producers. Particularly high was the rate of gelE-carrying strains expressing the gene. Data suggest that these two factors in particular may play an important role in enterococcal infections associated with biomaterials. |
doi_str_mv | 10.1177/039139880602900410 |
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We have examined a collection of 52 Enterococcus faecalis isolated from orthopedic infections to determine if they were characterized by a specific pattern of virulence factors. The isolates were evaluated for biofilm formation, presence of genes coding the enterococcal surface protein (esp) and gelatinase (gelE), as well as for gelatinase production. While the rate of esp-positive isolates was comparable to that found among strains from other clinical sources, we found a significantly higher rate of strong biofilm formers and gelatinase producers. Particularly high was the rate of gelE-carrying strains expressing the gene. 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subjects | Biofilms - growth & development Enterococcus faecalis Enterococcus faecalis - classification Enterococcus faecalis - genetics Enterococcus faecalis - isolation & purification Enterococcus faecalis - pathogenicity Gelatinases - genetics Gelatinases - metabolism Genes, Bacterial Gram-Positive Bacterial Infections - diagnosis Gram-Positive Bacterial Infections - microbiology Orthopedic Equipment - microbiology Virulence - genetics Virulence Factors |
title | Virulence factors in enterococcal infections of orthopedic devices |
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