Diagnosis of deep-seated lymphoma and leukemia by endoscopic ultrasound-guided fine-needle aspiration biopsy

We retrospectively studied the use of endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) as a tool for the diagnosis of deep-seated lymphoma. An on-site assessment at the time of EUS-FNAB was performed by a cytopathologist using Diff-Quik (American Scientific Products, McGraw Park...

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Bibliographic Details
Published in:American journal of clinical pathology 2006-05, Vol.125 (5), p.703-709
Main Authors: PUGH, Judith L, JHAIA, Nirag C, ELOUBEIDI, Mohamad A, CHHIENG, David C, ELTOUM, Isam A, CROWE, D. Ralph, VARADARAJULU, Shyam, JHALA, Darshana N
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biopsy, Fine-Needle
Endosonography - methods
Female
Flow Cytometry
Hematologic and hematopoietic diseases
Humans
Immunohistochemistry
Investigative techniques, diagnostic techniques (general aspects)
Leukemia, Hairy Cell - pathology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymph Nodes - pathology
Lymphoma - pathology
Male
Medical sciences
Middle Aged
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Predictive Value of Tests
Retrospective Studies
Sensitivity and Specificity
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Summary:We retrospectively studied the use of endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) as a tool for the diagnosis of deep-seated lymphoma. An on-site assessment at the time of EUS-FNAB was performed by a cytopathologist using Diff-Quik (American Scientific Products, McGraw Park, IL) stain. In addition, Papanicolaou stains were performed on EUS-FNAB smears, immunohistochemical stains were performed on cell blocks, and additional samples were sent for flow cytometric analysis. Final cytologic diagnosis was correlated with surgical pathology and/or clinical follow-up. We evaluated EUS-FNAB specimens of deep-seated lymph nodes, spleen, stomach, and pancreas, and 1 EUS-guided needle core biopsy specimen of a lymph node. Thirteen cases of deep-seated lymphoma were diagnosed, including non-Hodgkin lymphomas and Hodgkin lymphoma. One case of hairy cell leukemia was diagnosed. EUS-FNAB is a minimally invasive, cost-effective, and useful tool for the primary diagnosis or staging of deep-seated lymphomas.
ISSN:0002-9173
1943-7722
DOI:10.1309/9C8B78K0X27U77DC