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Molecular cloning and analysis of gonadal expression of Foxl2 in the medaka, Oryzias latipes
Foxl2 is a member of the winged helix/forkhead family of transcription factors and is known to be involved in ovarian development in some vertebrates. To address the role of Foxl2 in ovarian differentiation in medaka, we isolated Foxl2 cDNA and analyzed its expression patterns during sex differentia...
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| Published in: | Biochemical and biophysical research communications 2006-05, Vol.344 (1), p.353-361 |
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| cites | cdi_FETCH-LOGICAL-c500t-87b2481b52e5a7e348373f0f28a0876b554d3dae1f20680bb2a5e546f26f73cc3 |
| container_end_page | 361 |
| container_issue | 1 |
| container_start_page | 353 |
| container_title | Biochemical and biophysical research communications |
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| creator | Nakamoto, Masatoshi Matsuda, Masaru Wang, De-Shou Nagahama, Yoshitaka Shibata, Naoki |
| description | Foxl2 is a member of the winged helix/forkhead family of transcription factors and is known to be involved in ovarian development in some vertebrates. To address the role of
Foxl2 in ovarian differentiation in medaka, we isolated
Foxl2 cDNA and analyzed its expression patterns during sex differentiation. Expression of
Foxl2 started in somatic cells surrounding germ cells in XX gonads, just after initiation of ovarian differentiation, and was maintained in granulosa cells throughout ovarian development. In the adult ovary,
Foxl2 was expressed in previtellogenic and vitellogenic follicles, but expression ceased in postvitellogenic follicles. In contrast,
Foxl2 mRNA could not be detected in testes. In addition,
Foxl2 and
aromatase mRNAs were co-localized in some somatic cells located on the ventral side of developing XX gonads. Our results suggested that
Foxl2 was not involved in ovarian determination, but was involved in differentiation of granulosa cells in medaka. |
| doi_str_mv | 10.1016/j.bbrc.2006.03.137 |
| format | article |
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Foxl2 in ovarian differentiation in medaka, we isolated
Foxl2 cDNA and analyzed its expression patterns during sex differentiation. Expression of
Foxl2 started in somatic cells surrounding germ cells in XX gonads, just after initiation of ovarian differentiation, and was maintained in granulosa cells throughout ovarian development. In the adult ovary,
Foxl2 was expressed in previtellogenic and vitellogenic follicles, but expression ceased in postvitellogenic follicles. In contrast,
Foxl2 mRNA could not be detected in testes. In addition,
Foxl2 and
aromatase mRNAs were co-localized in some somatic cells located on the ventral side of developing XX gonads. Our results suggested that
Foxl2 was not involved in ovarian determination, but was involved in differentiation of granulosa cells in medaka.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2006.03.137</identifier><identifier>PMID: 16630569</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Amino Acid Sequence ; Animals ; Aromatase ; Aromatase - genetics ; Cell Differentiation - genetics ; Cloning, Molecular ; Estrogens - pharmacology ; Female ; Fish Proteins - genetics ; Fish Proteins - metabolism ; Folliculogenesis ; Forkhead Transcription Factors - genetics ; Forkhead Transcription Factors - metabolism ; Foxl2 ; Freshwater ; Granulosa cell ; Granulosa Cells - cytology ; Granulosa Cells - metabolism ; Hermaphroditic Organisms ; Male ; Medaka ; Molecular Sequence Data ; Oryzias - genetics ; Oryzias - growth & development ; Oryzias latipes ; Ovarian development ; Ovary - cytology ; Ovary - growth & development ; Ovary - metabolism ; RNA, Messenger - analysis ; RNA, Messenger - metabolism ; Sequence Alignment ; Sex Determination Processes ; Sex differentiation ; Sex Differentiation - genetics ; Teleost ; Testis - cytology ; Testis - drug effects ; Up-Regulation</subject><ispartof>Biochemical and biophysical research communications, 2006-05, Vol.344 (1), p.353-361</ispartof><rights>2006 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-87b2481b52e5a7e348373f0f28a0876b554d3dae1f20680bb2a5e546f26f73cc3</citedby><cites>FETCH-LOGICAL-c500t-87b2481b52e5a7e348373f0f28a0876b554d3dae1f20680bb2a5e546f26f73cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16630569$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakamoto, Masatoshi</creatorcontrib><creatorcontrib>Matsuda, Masaru</creatorcontrib><creatorcontrib>Wang, De-Shou</creatorcontrib><creatorcontrib>Nagahama, Yoshitaka</creatorcontrib><creatorcontrib>Shibata, Naoki</creatorcontrib><title>Molecular cloning and analysis of gonadal expression of Foxl2 in the medaka, Oryzias latipes</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Foxl2 is a member of the winged helix/forkhead family of transcription factors and is known to be involved in ovarian development in some vertebrates. To address the role of
Foxl2 in ovarian differentiation in medaka, we isolated
Foxl2 cDNA and analyzed its expression patterns during sex differentiation. Expression of
Foxl2 started in somatic cells surrounding germ cells in XX gonads, just after initiation of ovarian differentiation, and was maintained in granulosa cells throughout ovarian development. In the adult ovary,
Foxl2 was expressed in previtellogenic and vitellogenic follicles, but expression ceased in postvitellogenic follicles. In contrast,
Foxl2 mRNA could not be detected in testes. In addition,
Foxl2 and
aromatase mRNAs were co-localized in some somatic cells located on the ventral side of developing XX gonads. Our results suggested that
Foxl2 was not involved in ovarian determination, but was involved in differentiation of granulosa cells in medaka.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Aromatase</subject><subject>Aromatase - genetics</subject><subject>Cell Differentiation - genetics</subject><subject>Cloning, Molecular</subject><subject>Estrogens - pharmacology</subject><subject>Female</subject><subject>Fish Proteins - genetics</subject><subject>Fish Proteins - metabolism</subject><subject>Folliculogenesis</subject><subject>Forkhead Transcription Factors - genetics</subject><subject>Forkhead Transcription Factors - metabolism</subject><subject>Foxl2</subject><subject>Freshwater</subject><subject>Granulosa cell</subject><subject>Granulosa Cells - cytology</subject><subject>Granulosa Cells - metabolism</subject><subject>Hermaphroditic Organisms</subject><subject>Male</subject><subject>Medaka</subject><subject>Molecular Sequence Data</subject><subject>Oryzias - genetics</subject><subject>Oryzias - growth & development</subject><subject>Oryzias latipes</subject><subject>Ovarian development</subject><subject>Ovary - cytology</subject><subject>Ovary - growth & development</subject><subject>Ovary - metabolism</subject><subject>RNA, Messenger - analysis</subject><subject>RNA, Messenger - metabolism</subject><subject>Sequence Alignment</subject><subject>Sex Determination Processes</subject><subject>Sex differentiation</subject><subject>Sex Differentiation - genetics</subject><subject>Teleost</subject><subject>Testis - cytology</subject><subject>Testis - drug effects</subject><subject>Up-Regulation</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqFkMFO3DAQhi0Egi30BTggnziRdGzHdiJxQQjaSlRcQOJQyXKcCXjxxoudrVievlntStzaw2ikme__Dx8hpwxKBkx9m5dtm1zJAVQJomRC75EZgwYKzqDaJzOYPgVv2NMR-ZLzHICxSjWH5IgpJUCqZkZ-_4oB3SrYRF2Igx-eqR26aWxYZ59p7OlzHGxnA8X3ZcKcfRw219v4Hjj1Ax1fkC6ws6_2gt6n9Ye3mQY7-iXmE3LQ25Dx624fk8fbm4frH8Xd_fef11d3hZMAY1Hrllc1ayVHaTWKqhZa9NDz2kKtVStl1YnOIus5qBralluJslI9V70Wzoljcr7tXab4tsI8moXPDkOwA8ZVNko3NZON_i_INGsqDc0E8i3oUsw5YW-WyS9sWhsGZiPfzM1GvtnINyDMJH8Kne3aV-1k5DOysz0Bl1sAJxl_PCaTncfBYecTutF00f-r_y8eOZUm</recordid><startdate>20060526</startdate><enddate>20060526</enddate><creator>Nakamoto, Masatoshi</creator><creator>Matsuda, Masaru</creator><creator>Wang, De-Shou</creator><creator>Nagahama, Yoshitaka</creator><creator>Shibata, Naoki</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20060526</creationdate><title>Molecular cloning and analysis of gonadal expression of Foxl2 in the medaka, Oryzias latipes</title><author>Nakamoto, Masatoshi ; Matsuda, Masaru ; Wang, De-Shou ; Nagahama, Yoshitaka ; Shibata, Naoki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-87b2481b52e5a7e348373f0f28a0876b554d3dae1f20680bb2a5e546f26f73cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Aromatase</topic><topic>Aromatase - genetics</topic><topic>Cell Differentiation - genetics</topic><topic>Cloning, Molecular</topic><topic>Estrogens - pharmacology</topic><topic>Female</topic><topic>Fish Proteins - genetics</topic><topic>Fish Proteins - metabolism</topic><topic>Folliculogenesis</topic><topic>Forkhead Transcription Factors - genetics</topic><topic>Forkhead Transcription Factors - metabolism</topic><topic>Foxl2</topic><topic>Freshwater</topic><topic>Granulosa cell</topic><topic>Granulosa Cells - cytology</topic><topic>Granulosa Cells - metabolism</topic><topic>Hermaphroditic Organisms</topic><topic>Male</topic><topic>Medaka</topic><topic>Molecular Sequence Data</topic><topic>Oryzias - genetics</topic><topic>Oryzias - growth & development</topic><topic>Oryzias latipes</topic><topic>Ovarian development</topic><topic>Ovary - cytology</topic><topic>Ovary - growth & development</topic><topic>Ovary - metabolism</topic><topic>RNA, Messenger - analysis</topic><topic>RNA, Messenger - metabolism</topic><topic>Sequence Alignment</topic><topic>Sex Determination Processes</topic><topic>Sex differentiation</topic><topic>Sex Differentiation - genetics</topic><topic>Teleost</topic><topic>Testis - cytology</topic><topic>Testis - drug effects</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakamoto, Masatoshi</creatorcontrib><creatorcontrib>Matsuda, Masaru</creatorcontrib><creatorcontrib>Wang, De-Shou</creatorcontrib><creatorcontrib>Nagahama, Yoshitaka</creatorcontrib><creatorcontrib>Shibata, Naoki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakamoto, Masatoshi</au><au>Matsuda, Masaru</au><au>Wang, De-Shou</au><au>Nagahama, Yoshitaka</au><au>Shibata, Naoki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular cloning and analysis of gonadal expression of Foxl2 in the medaka, Oryzias latipes</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2006-05-26</date><risdate>2006</risdate><volume>344</volume><issue>1</issue><spage>353</spage><epage>361</epage><pages>353-361</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Foxl2 is a member of the winged helix/forkhead family of transcription factors and is known to be involved in ovarian development in some vertebrates. To address the role of
Foxl2 in ovarian differentiation in medaka, we isolated
Foxl2 cDNA and analyzed its expression patterns during sex differentiation. Expression of
Foxl2 started in somatic cells surrounding germ cells in XX gonads, just after initiation of ovarian differentiation, and was maintained in granulosa cells throughout ovarian development. In the adult ovary,
Foxl2 was expressed in previtellogenic and vitellogenic follicles, but expression ceased in postvitellogenic follicles. In contrast,
Foxl2 mRNA could not be detected in testes. In addition,
Foxl2 and
aromatase mRNAs were co-localized in some somatic cells located on the ventral side of developing XX gonads. Our results suggested that
Foxl2 was not involved in ovarian determination, but was involved in differentiation of granulosa cells in medaka.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16630569</pmid><doi>10.1016/j.bbrc.2006.03.137</doi><tpages>9</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 2006-05, Vol.344 (1), p.353-361 |
| issn | 0006-291X 1090-2104 |
| language | eng |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Amino Acid Sequence Animals Aromatase Aromatase - genetics Cell Differentiation - genetics Cloning, Molecular Estrogens - pharmacology Female Fish Proteins - genetics Fish Proteins - metabolism Folliculogenesis Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Foxl2 Freshwater Granulosa cell Granulosa Cells - cytology Granulosa Cells - metabolism Hermaphroditic Organisms Male Medaka Molecular Sequence Data Oryzias - genetics Oryzias - growth & development Oryzias latipes Ovarian development Ovary - cytology Ovary - growth & development Ovary - metabolism RNA, Messenger - analysis RNA, Messenger - metabolism Sequence Alignment Sex Determination Processes Sex differentiation Sex Differentiation - genetics Teleost Testis - cytology Testis - drug effects Up-Regulation |
| title | Molecular cloning and analysis of gonadal expression of Foxl2 in the medaka, Oryzias latipes |
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