Polymorphism of the 3'-Untranslated Region of Interleukin-12 p40 Gene is not Associated With the Presence or Severity of Coronary Artery Disease

Background Interleukin (IL)-12 is thought to play an important role in the development of atherosclerosis and recently, polymorphism of the 3'-untranslated region of the IL-12 p40 gene (A1188C) was reported to be associated with diabetes and multiple sclerosis. However, the association between...

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Bibliographic Details
Published in:Circulation Journal 2005, Vol.69(7), pp.793-797
Main Authors: Momiyama, Yukihiko, Ohmori, Reiko, Nagano, Makoto, Kato, Ryuichi, Taniguchi, Hiroaki, Egashira, Tohru, Nakamura, Haruo, Ohsuzu, Fumitaka
Format: Article
Language:English
Subjects:
Aged
Coronary artery disease
Coronary Artery Disease - complications
Coronary Artery Disease - genetics
Genetics
Humans
Interleukin-12
Interleukin-12 - genetics
Interleukin-12 Subunit p40
Male
Middle Aged
Myocardial Infarction - etiology
Myocardial Infarction - genetics
Polymorphism
Polymorphism, Single Nucleotide
Severity of Illness Index
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Summary:Background Interleukin (IL)-12 is thought to play an important role in the development of atherosclerosis and recently, polymorphism of the 3'-untranslated region of the IL-12 p40 gene (A1188C) was reported to be associated with diabetes and multiple sclerosis. However, the association between this genetic polymorphism and coronary artery disease (CAD) has not been studied. Methods and Results The frequency of this polymorphism was investigated in 555 patients undergoing coronary angiography: 395 had CAD, of whom 161 also had a myocardial infarction (MI). With regard to the IL-12 p40 polymorphism, 125 had the A/A, 268 had the A/C, and 162 had the C/C genotype. The prevalence of CAD did not differ among the groups (71%, 73%, and 69%, respectively; p= NS). The prevalence of MI was also similar among the groups (28%, 27%, and 33%, respectively; p= NS). Moreover, the number of >50% stenotic vessels, >50% stenotic segments, and ≤50% stenotic segments did not differ among the 3 groups. Conclusions Polymorphism of IL-12 p40 gene was not found to be associated with the presence or severity of CAD, suggesting that it does not play an important role in the development of this disease. (Circ J 2005; 69: 793 - 797)
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.69.793