Y-chromosome STR haplotype diversity in three ethnic populations in Singapore

In this study, 12 Y-STR loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385a/b, DYS437, DYS438 and DYS439) were genotyped in the three major ethnic populations in Singapore, namely the Chinese, Malay and Indian. Allele frequency distribution, locus diversity, haplotype diversity a...

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Bibliographic Details
Published in:Forensic science international 2006-06, Vol.159 (2), p.244-257
Main Authors: Yong, R.Y.Y., Lee, L.K.H., Yap, E.P.H.
Format: Article
Language:English
Subjects:
Allele frequencies
Analysis
Armed forces
Asian
Asian Continental Ancestry Group - genetics
Biological and medical sciences
Chromosomes, Human, Y - genetics
Ethnic groups
Forensic medicine
Forensic sciences
Frequency distribution
General aspects
Genetic aspects
Genetics
Genetics, Population
Haplotypes
Human population genetics
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Minority & ethnic groups
Population data
Public health. Hygiene
Public health. Hygiene-occupational medicine
Quality control
Short tandem repeats
Singapore
Singaporeans
Tandem Repeat Sequences - genetics
Y chromosome
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Summary:In this study, 12 Y-STR loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385a/b, DYS437, DYS438 and DYS439) were genotyped in the three major ethnic populations in Singapore, namely the Chinese, Malay and Indian. Allele frequency distribution, locus diversity, haplotype diversity and discrimination capacity were estimated. Analysis of molecular variance between the three ethnic populations indicated that 87.71% of the haplotypic variation is found within population and 12.29% is between populations (Fixation Index F ST = 0.123, p = 0.000). Population pairwise comparisons showed significant Phist values between all population pairs, with the lowest ( R ST = 0.05) for Chinese–Malay and the highest ( R ST = 0.19) for Chinese–Indian.
ISSN:0379-0738
1872-6283
DOI:10.1016/j.forsciint.2005.05.010