Two consecutive immunophenotypic switches in a child with MLL-rearranged acute lymphoblastic leukemia

An 18-month-old girl was diagnosed with pre-pre-B ALL/t(4;11) leukemia, which during the treatment and after matched bone marrow transplantation (BMT), underwent two consecutive switches from lymphoid to myeloid lineage and vice versa. The high expression of HOXA9 and FLT3 genes remaining genotypica...

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Bibliographic Details
Published in:Haematologica (Roma) 2006-05, Vol.91 (5 Suppl), p.ECR09-ECR09
Main Authors: Germano, Giuseppe, Pigazzi, Martina, del Giudice, Laura, Campo Dell'Orto, Marta, Spinelli, Monica, Zangrando, Andrea, Paolucci, Paolo, Ladogana, Saverio, Basso, Giuseppe
Format: Article
Language:English
Subjects:
Antigens, CD - analysis
Antigens, Neoplasm - analysis
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
B-Lymphocytes - immunology
B-Lymphocytes - pathology
Cell Lineage
Chromosomes, Human, Pair 11 - genetics
Chromosomes, Human, Pair 11 - ultrastructure
Chromosomes, Human, Pair 4 - genetics
Chromosomes, Human, Pair 4 - ultrastructure
Clone Cells - pathology
Combined Modality Therapy
Fatal Outcome
Female
fms-Like Tyrosine Kinase 3 - genetics
Gene Expression Regulation, Leukemic
Gene Rearrangement
Gene Rearrangement, B-Lymphocyte
Genes, Immunoglobulin
Hematopoietic Stem Cells - immunology
Hematopoietic Stem Cells - pathology
Histone-Lysine N-Methyltransferase
Homeodomain Proteins - genetics
Humans
Immunophenotyping
Infant
Models, Biological
Myeloid-Lymphoid Leukemia Protein - genetics
Neoplasm Proteins - genetics
Oncogene Proteins, Fusion - genetics
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - surgery
Recurrence
Translocation, Genetic
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Summary:An 18-month-old girl was diagnosed with pre-pre-B ALL/t(4;11) leukemia, which during the treatment and after matched bone marrow transplantation (BMT), underwent two consecutive switches from lymphoid to myeloid lineage and vice versa. The high expression of HOXA9 and FLT3 genes remaining genotypically stable in a leukemia throughout phenotypic switches, suggests that this leukemia may have originated as a common B/myeloid progenitors.
ISSN:1592-8721