Efficient C−C Double-Bond Formation Reaction via a New Synthetic Strategy:  A Self-Sorting Tandem Reaction

A novel and efficient carbon−carbon double-bond formation reaction via coupling of aryl or heteroaryl methyl ketones has been developed. A dimethyl sulfoxide−iodine−CuO system was proven to be efficient for this reaction and afforded the expected products in good yields. A new synthetic strategy, a...

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Bibliographic Details
Published in:Organic letters 2006-05, Vol.8 (11), p.2245-2248
Main Authors: Yin, Guodong, Zhou, Baohan, Meng, Xianggao, Wu, Anxin, Pan, Yuanjiang
Format: Article
Language:English
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Summary:A novel and efficient carbon−carbon double-bond formation reaction via coupling of aryl or heteroaryl methyl ketones has been developed. A dimethyl sulfoxide−iodine−CuO system was proven to be efficient for this reaction and afforded the expected products in good yields. A new synthetic strategy, a self-sorting tandem reaction, was involved in this type of reaction and was presented for the first time.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol060541e