Predictors of response to cardiac resynchronization therapy (PROSPECT)—study design

Cardiac resynchronization therapy (CRT) is currently indicated in patients with moderate to severe heart failure, a wide QRS complex and significant left ventricular dysfunction despite optimal medical therapy. Adoption of these criteria for CRT results in a favorable response in only two thirds of...

Full description

Saved in:
Bibliographic Details
Published in:The American heart journal 2005-04, Vol.149 (4), p.600-605
Main Authors: Yu, Cheuk-Man, Abraham, William T., Bax, Jeroen, Chung, Eugene, Fedewa, Michelle, Ghio, Stefano, Leclercq, Christophe, León, Angel R., Merlino, John, Nihoyannopoulos, Petros, Notabartolo, Dean, Ping Sun, Jing, Tavazzi, Luigi
Format: Article
Language:English
Subjects:
Asia
Biological and medical sciences
Cardiology. Vascular system
Drug therapy
Echocardiography, Doppler
Electric Countershock
Endpoint Determination
Europe
Forecasting
Heart attacks
Heart failure
Heart Failure - diagnostic imaging
Heart Failure - therapy
Humans
Informed consent
Medical sciences
Patient Selection
Prospective Studies
Quality of Life
Research Design
Sample Size
Studies
Transplants & implants
Treatment Outcome
United States
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Dysfunction, Left - therapy
Ventricular Function, Left
Ventricular Remodeling
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cardiac resynchronization therapy (CRT) is currently indicated in patients with moderate to severe heart failure, a wide QRS complex and significant left ventricular dysfunction despite optimal medical therapy. Adoption of these criteria for CRT results in a favorable response in only two thirds of candidates. “Predictors of response to cardiac resynchronization therapy (PROSPECT),” a prospective, multicenter, nonrandomized study, aims to identify echocardiographic measures of dyssynchrony and evaluate their ability to predict response to CRT. PROSPECT will enroll approximately 300 patients in up to 75 centers in the United States, Asia, and Europe with clinical follow-up for 6 months. We will prospectively and individually test a variety of conventional echocardiographic and tissue Doppler imaging parameters against measures of clinical response. The primary response criteria are improvement in the heart failure Clinical Composite Score and left ventricular reverse remodeling. Enrollment began in March 2004 and is expected to conclude early 2005.
ISSN:0002-8703
1097-6744
DOI:10.1016/j.ahj.2004.12.013